Abstract

Objective: In this study, we aimed to examine and evaluate the demographic data and malnutrition of patients we followed up with a diagnosis of CD.

Material and Methods: The files of 113 children aged between 2 and 18 years who were followed up with a diagnosis of CD from the Pediatric Gastroenterology Outpatient Clinic of our tertiary hospital were retrospectively analyzed. Diagnosis of CD; Patients with symptoms of the disease (abdominal pain, diarrhea, growth retardation, etc.), whose tissue transglutaminase values were positive, were examined by endoscopic method, and were classified according to the MARS classification, which was biopsied and made by the pathology clinic. The malnutrition status of these children was examined by looking at their calendar age, gender, weight and height, weight for age, weight for height, and body mass index (BMI). In addition, nutritional status was evaluated by looking at hemoglobin, ferritin, iron and vitamin B12 values.

Results: A total of 113 patients, 75 (66.4%) female and 38 (33.6%) male, who were diagnosed with CD and followed up were included in the study. When the weight values of the patients were examined, the 3rd percentile was 23%, the 3-10th percentile was 16.8%, the 10-25p was 16.8%, the 25-97th percentile was 41.6%, and the above 97th percentile was 1.8%. According to Gomez classification, mild malnutrition was 34.5%, moderate malnutrition 18.5% and heavy malnutrition 1.7%, weight for height was found to be mild 24.8%, moderate 3.5%, malnutrition, 16.8% according to BMI. Vitamin B12 deficiency was found 39%, low hemoglobin 22%, low ferritin 45% and iron deficiency 30%.

Conclusion: Malnutrition in CD continues to be an important problem. Malnutrition status in our study; Malnutrition was determined as 54.7% by weight for age, 28.3% for weight for height and 16.8% for BMI. Broader studies are required to minimize the negative effects of CD and related malnutrition in the world and in our country.

Keywords: Child, Celiac, Malnutrition

References

  1. 1-Trancone R, Jabri B. Celiacdiseaseandglutensensitivity. J InternMed 2011;269:582-90.,Shahrooz R, Murray JA. Celiacdisease: newapproachestotherapy. AlimentPharmacolTher 2012; 35: 768–781
  2. 2-Naiyana G, Hugh JF, Alan T. Celiacdisease: Prevalence, diagnosis,pathogenesisandtreatment World J Gastroenterol 2012;18):6036-59).
  3. 3-Rampertab SD, Pooran N, Brar P, Singh P, Green PH. Trends in thepresentation of celiacdisease. Am J Med 2006; 119: 355.e9-14.
  4. 4-Alleyne GAO, Hay RW, Picou DI, Stanfield J P & Whitehead R G. Protein-energyMalnutrition, FromeandLondon: Buttler&TannerLtd, 1979: 171- 4
  5. 5-Grover Z, C Ee L. Protein energymalnutrition. Pediatr Clin North Am 2009;56:1055-58.
  6. 6-Dipasquale V, Ugo Cucinotta U, Romano C. AcuteMalnutrition in Children: Pathophysiology, ClinicalEffectsandTreatment. Nutrients 2020;12:2413.
  7. 7-Özdemir N, Çocuklarda tanıdan tedaviye demir eksikliği anemisi Türk Ped Arş 2015; 50: 11-9
  8. 8-Waterlow JC. Classificationanddefinition of protein-caloriemalnutrition. BrMed J 1972;3:566-569. http://dx.doi.org/10.1136/bmj.3.5826.566 PMid:4627051 PMCid:1785878
  9. 9-Waterlow JC, Buzina R, Keller W, Lane JM, Nichaman MZ, Tanner JM. Thepresentationanduse of heightandweightdataforcomparingthenutritionalstatus of groups of childrenundertheage of 10 years. Bull World Health Organ 1977;55:489-498. PMid:304391 PMCid:2366685
  10. 10-Hill ID, Dirks MH, Liptak GS, Colletti, RB, Fasano, A, Guandalini, S. et al. Guidelineforthediagnosisandtreatment of celiacdisease in children: recommendations of theNorth AmericanSocietyforPediatricGastroenterology, HepatologyandNutrition. J Pediatr GastroenterolNutr 2005;40:1-19.
  11. 11-Dalgic B, Sari S, Basturk B, Ensari A, Egritas O, Bukulmez A ve ark. TurkishCeliacStudyGroup. Prevalence of celiacdisease in healthyTurkishschoolchildren. Am J Gastroenterol 2011; 106: 1512-1517.
  12. 12-Eaton WW, Rose NR, Kalaydjian A, Pedersen MG, Mortensen PB. Epidemiology of autoimmunediseases in Denmark. J Autoimmun. Epub 2007 Jun 19. PMID: 17582741; PMCID: PMC2717015.
  13. 13-Kuloglu Z, Doganci T, Kansu A, Demirceken F, Duman M, Tutkak H, ve ark. HLA types in Turkish children with celiac disease. Turk JPediatr 2008;50: 515–20
  14. 14-Emiroğlu HH, Emiroğlu E, Akbulut H, Eryılmaz A, Bayram RO, Yüksel A ve ark. Çölyak Hastalığı Tanısı ile İzlenen Çocuklarda Klinik Özellikler J CONTEMP MED 2017; 7(4): 333-339
  15. 15-Castro-Antunes MM, Crovella S, Brandao LA, Guimaraes RL, Motta ME, Silva GA. Frequencydistribution of HLA DQ2 and DQ8 in celiac patients and first-degreerelatives in Recife, North eastern Brazil. Clinics (Sao Paulo) 2011;66: 227–31
  16. 16-Dahele A, Ghosh S. Vitamin B12 deficiency in untreated celiac disease. Am J Gastroenterol 2001;96: 745-50
  17. 17-Basturk A. Yılmaz R. Çölyak Hastalıklı Çocuk Hastalarımızın Retrospektif Olarak Değerlendirilmesi, Uludağ Üniversitesi Tıp Fakültesi Dergisi 42 (2-3) 79-82, 2016)
  18. 18-Albayrak S, Doğan Y (2016). Çölyak Hastalığı Olan Çocukların Klinik Ve Laboratuvar Bulgularının Retrospektif Olarak Değerlendirilmesi 2016, Uzmanlık Tezi, Fırat Üniversitesi Tıp Fakültesi Çocuk Sağlığı Ve Hastalıkları Kliniği, Elazığ
  19. 19-Mokhtari H, .Kuloğlu Z (2012). Çölyak Hastalığı Tanısı Alan Çocuklarda Şişmanlık Sıklığı Ve Glutensiz Diyetin Vücut Kitle İndeksine Etkisi Uzmanlık Tezi, Ankara Üniversitesi Tıp Fakültesi Çocuk Sağlığı Ve Hastalıkları Kliniği, Ankara

Copyright and license

How to cite

1.
Ballı H, Dereci S, Aşık A. Malnutrition Status of Children with Celiac Disease. Turk J Pediatr Dis [Internet]. 2021 Nov. 26 [cited 2025 May 24];15(6):526-30. Available from: https://turkjpediatrdis.org/article/view/745