Abstract

Objective: In this study, booster dose vaccine response was evaluated after performing a vaccine schedule at 0,

1st and 6th months among 83 children aged between 2 and 16 years who were primary hepatitis B vaccine nonresponders

and we tried to determine which groups were sensitive concerning vaccine response.

Material and Methods: Euvax B vaccine which included 10 μg HBsAg was administered in 3 doses for the second

time at 0, 1 and 6 months as 0.5 ml intramuscularly in the deltoid muscle to 83 healthy children aged between 2 and 16

years who were primary hepatitis B vaccine non-responders and their vaccine status was determined with tests before

minor surgery. Blood tests were taken three times from children at 1, 6 and 7 months after the first vaccination and anti-

HBs titer was evaluated by using enzyme-linked immunosorbent assay technique.

Results: The mean age of the children was 9.3±3.6 years (2-15,9 years). The anti-HBs geometric mean concentration

was found to be 537.97±377.51 mIU/mL (0.6-1000) after the first vaccination, as 309.33± 337.45 mIU/mL (8-1000)

after the second vaccination and as 609.78±347.43 mIU/mL (11.1-1000) following the third vaccination. Anti-HBs

positive conversion rates in T1 were compared in 81 children who had been checked after the first vaccination and anti-

HBs positive conversion rates were found to be significantly lower in children whose anti-HBs titer was under 1 mlU/ml

before vaccination (p=0,01, Z -3.29, U 469). There was no difference concerning T6 and T7 between these two groups.

Anti-HBs positive conversion rates in T6 and T7 were found to be significantly higher in children with malnutrition

(p=0.008, Z -2.56, U 60.5, p=0.03, Z -2.11, U 26.5).

Conclusion: When observing the rapid decrease in T6 in contrast with the two dose vaccination, it is thought that anti-

HBs seroconversion rates and anti-HBs geometric mean concentration are related with reminding, anti-HBs titer before

vaccination and checking time of anti-HBs rather than the number of reminding doses. In fact, we believe that 3 dose






vaccination is better among those children whose anti-HBs titer is under <1 mIU/mL and who have malnutrition.

Keywords: Booster vaccination, Child, Hepatitis B virus

References

  1. 1. Immunization Coverage. Availablefrom:http://www.who.int/mediacentre/
  2. factsheets/fs378/en/. Accessed date: 1 Haziran, 2016
  3. 2. Zhuang GH,Yan H, Wang XL. Risk factors of and mechanism for
  4. non-responsiveness to hepatitis B vaccination. Zhonghua Gan
  5. Zang Bing Za Zhi 2006;14:157-60.
  6. 3. Averhoff F, Mahoney F, Coleman P, Schatz G, Hurwitz E, Margolis
  7. H. Immunogenicity of hepatitis B Vaccines. Implications for persons
  8. at occupational risk of hepatitis B virus infection. Am J Prev Med
  9. 1998;15:1–8.
  10. 4. http://www.cdc.gov/vaccines/pubs/pinkbook/hepb.html
  11. (8.5.2017)
  12. 5. Toy M, Önder FO, Wörmann T, Bozdayi AM, Schalm SW, Borsboom
  13. GJ, et al. Age- and region-specific hepatitis B prevalence in Turkey
  14. estimated using generalized linear mixed models: A systematic
  15. review. BMC Infectious Diseases 2011;11:337.
  16. 6. Bonanni P, Pesavento G, Boccalini S, Bechini A. Perspectives of
  17. public health: Present and foreseen impact of vaccination on the
  18. epidemiology of hepatitis B. J Hepatol 2003;39:224-9.
  19. 7. Ozmert EN. Dünya’da ve Türkiye’de aşılama takvimindeki
  20. gelişmeler. Çocuk Sağlığı ve Hastalıkları Dergisi 2008;51:168-75.
  21. 8. Jafarzadeh A, Zarei S, Shokri F. Low dose revaccination induces
  22. robust protective anti-HBs antibody response in the majority of
  23. healthy non-responder neonates. Vaccine 2008;26:269-76.

Copyright and license

How to cite

1.
Kara Uzun A. Booster Dose Vaccine Response among Children Who were Primary Hepatitis B Vaccine Non-Responders and Sensitive Groups Concerning Vaccine Response. Turk J Pediatr Dis [Internet]. 2019 May 24 [cited 2025 May 25];13(3):160-4. Available from: https://turkjpediatrdis.org/article/view/607