Abstract

Objective: Chlorine gas (Cl2) is a common substance used in industry, which causes toxic inhalation as a potent pulmonary irritant. Herein, we aimed to investigate the findings of pediatric cases accidentally exposed to Cl2 gas.

Material and Methods: In October 2017, an accident involving Cl2 gas exposure occurred in a school where 650 students were trained.

Results: Fifty students breathed in the steam generated in the school hallway as a result of an accident during cleaning The mean age of the patients was 11.2±1.5 years (range 2–18 years); 62% of the children were male. Among patients evaluated at the emergency department, 21 (42%) patients were discharged within 4-6 hours after the initial examination and symptomatic treatment. The remaining 29 patients were hospitalized. The presenting symptoms were mostly associated with one another, which included cough and dyspnea (n=30, 60%), nausea and vomiting (n=6, 12%), headache (n=7, 14%), and sore throat (n=3, 6%). Thirty patients had elevated creatine kinase-MB (CK-MB) (mean 54.9±50.1 U/L). Five patients had sinus tachycardia on electrocardiogram. During the follow-up period, cardiac enzymes of all patients returned to normal levels. Seven patients were treated with steroids, bronchodilators, and humidified oxygen; 11 patients were treated with oxygen and bronchodilators; the remainders took oxygen alone.

Conclusion: We suggest that this study will contribute to raising awareness about chemicals that can produce toxic substances, as in our cases.

Keywords: Bleach, hydrochloric acid, chlorine gas, pediatric

References

  1. White CW, Martin JG. Chlorine gas inhalation: human clinical evidence of toxicity and experience in animal models. Proc Am Thorac Soc 2010; 7:257–63.
  2. Deschamps D, Soler P, Rosenberg N, Baud F, Gervais P. Persistent asthma after inhalation of a mixture of sodium hypochlorite and hydrochloric acid. Chest 1994;105:1895-6.
  3. Slaughter RJ, Watts M, Vale JA, Grieve JR, Schep LJ. The clinical toxicology of sodium hypochlorite. Clin Toxicol (Phila) 2019; 57: 303-11.
  4. Guloglu C, Kara IH, Erten PG. Acute accidental exposure to chlorine gas in the Southeast of Turkey: a study of 106 cases. Environ Res 2002;88:89-93.
  5. Agabiti N, Ancona C, Forastiere F, Di Napoli A, Lo Presti effects of acute exposure to chlorine due to a swimming pool accident. Occup Environ Med 2001;58:399-404.
  6. Mrvos R, Dean BS, Krenzelok EP. Home exposures to chlorine/chloramine gas: review of 216 cases. South Med J 1993;86:654-7.
  7. Gunnarsson M, Walther SM, Seidal T, Lennquist S. Effects of inhalation of corticosteroids immediately after experimental chlorine gas lung injury. J Trauma 2000;48:101-7.
  8. Martinez TT, Long C. Explosion risk from swimming pool chlorinators and review of chlorine toxicity. J Toxicol Clin Toxicol 1995;33:349-54.
  9. Fleta J, Calvo C, Zuniga J, Castellano M, Bueno M. Intoxication of 76 children by chlorine gas. Hum Toxicol 1986;5:99-100.
  10. Squadrito GL, Postlethwait EM, Matalon S. Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications. Am J Physiol Lung Cell Mol Physiol 2010; 299:L289–300.
  11. Hawkins CL, Pattison DI, Davies MJ. Hypochlorite-induced oxidation of amino acids, peptides and proteins. Amino Acids 2003; 25:259–74.
  12. Evans RB. Chlorine: state of the art. Lung 2005;183:151-67.13. Donnelly SC, FitzGerald MX. Reactive airways dysfunction syndrome (RADS) due to chlorine gas exposure. Ir J Med Sci 1990;159:275-6.
  13. Donnelly SC, FitzGerald MX. Reactive airways dysfunction syndrome (RADS) due to chlorine gas exposure. Ir J Med Sci 1990;159:275-6.
  14. Howard C, Ducre B, Burda AM, Kubic A. Management of chlorine gas exposure. J Emerg Nurs 2007;33:402- 4.
  15. den Hartog GJ, Haenen GRMM, Vegt E, van der Vijgh WJF, Bast A. Efficacy of HOCl scavenging by sulfur-containing compounds: antioxidant activity of glutathione disulfide? Biol Chem 2002; 383:709–13.
  16. Mohapatra S, Agarwal V, Sitholey P. Pediatric anxiety disorders. Asian J Psychiatr 2013; 6:356-63.
  17. Szerlip HM, I Singer I. Hyperchloremic metabolic acidosis after chlorine inhalation. Am J Med 1984; 77:581-2.
  18. Vengust M. Hypercapnic respiratory acidosis: A protective or harmful strategy for critically ill newborn foals? Can J Vet Res 2012; 76:275–80.
  19. Krapf R, Beeler I, Hertner D, Hulter HN. Chronic respiratory alkalosis. The effect of sustained hyperventilation on renal regulation of acid-base equilibrium. N Engl J Med 1991; 324:1394-401.
  20. Runyan C. Using the Haddon Matrix: Introducing the third dimension. Injury Prevention 1998; 4:302–7.

How to cite

1.
Tursun S, Alpcan A, Kandur Y. Clinical Spectrum of Acute Chlorine Poisoning in Children. Turk J Pediatr Dis [Internet]. 2022 Jan. 28 [cited 2025 Aug. 23];16(1):49-52. Available from: https://turkjpediatrdis.org/article/view/918