Abstract
Introduction: Many predictive biomarkers were developed to evaluate
the prognosis and mortality of critically ill children. Serum lactate level is
one common biomarker because hyperlactatemia is associated with mortality in these
patients. Previous studies have shown that serum albumin level is also a useful
biomarker. Several recent articles suggested that the combination of serum
lactate and albumin is a more effective predictor of mortality in critically
ill patients. This study aimed to determine whether the lactate/albumin (L/A) ratio
was a better prognostic factor than serum lactate level alone.
Material and Methods: Thus, we retrospectively investigated the relationship between these biomarkers and their
relationship with invasive
mechanical ventilation, noninvasive mechanical ventilation support, inotropic
drug need, acute renal kidney injury, continuous renal replacement therapy,
mortality, and hospitalisation period.
Results: A total of 379 patients with a mean age of 4.8±5.3 years (range,
1 month to 18 years) were included in this study. The average duration of stay
in the paediatric intensive care unit was 7.4±11.5
days, and the median L/A ratio
was 0.46 (range, 0.11–10.0). Our findings indicate that the L/A ratio and serum
lactate level were associated with mortality in critically ill children.
However, our analysis also suggested that an L/A ratio of >0.5 upon
admission is an overall better predictor of mortality.
Conclusion:We conclude that the L/A ratio is a useful and
effective predictor of mortality in critically ill children.
Keywords: Paediatric intensive care unit, prognosis, lactate, albumin
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