Abstract

Objective: Cholestasis in childhood results from different etiologies according to age groups. The differences between clinical and
laboratory findings in patients with cholestasis during the first 3 months of age and after 3 months are unknown. The aim of this study is
to investigate the clinical, laboratory; and histopathological findings of patients with cholestasis according to age groups.
Material and Methods: Between January 2013-March 2017, files of the patients diagnosed as cholestasis in 0-18 year of age were
retrospectively reviewed. Demographic data, complaints, physical examination, laboratory, ultrasonography and if liver biopsy is done
histopathologic findings of the patients were recorded.
Results: Forty-four patients (29 M, 65%) were diagnosed as cholestasis during the study period. Twenty-five (56%) of the patients were
younger than 3 months (Group 1), 19 (44%) of the patients were older than 3 months (Group 2). The patients were diagnosed as cholestasis
in the first 3 months were idiopathic neonatal hepatitis (n=5, 20%), non-syndromic paucity of intrahepatic bile ducts (n=5, 20%), biliary
atresia (n=3, 12%), progressive familial intrahepatic cholestasis (n=3, 12%), cholestasis owing to prematurity/ sepsis/ parenteral nutrition
(n=3, 12%) respectively. Aetiology of the cholestasis after 3 months were cryptogenic hepatitis (n=5, 26.3%) and autoimmune hepatitis
(n=4, 21%) respectively. Mean duration of follow up was 17.7±15.1 months. Total and direct bilirubin levels were higher in Group 1 patients
(p=0.017 and p= 0.023 respectively) whereas albumin levels were lower (p=0.051). Ultrasonographic evaluation revealed statistically
homogenic liver parenchyma in Group 1 (p=0.000). Liver histopathologic examination showed fibrosis in Group 2 (p=0.000).
Conclusion: Cholestasis in childhood occurs different reasons. Although bilirubin levels were higher in young children, chronic changes such
as liver fibrosis are common in older children.

Keywords: Child, Infant, Cholestasis, Liver diseases

References

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How to cite

1.
Demir AM, Yaman A, Hızal G, Berberoğlu Ateş B, Tuna Kırsaçlıoğlu C, Ece D, et al. Evaluation of Clinical and Laboratory Findings in Childhood Cholestasis According To Age Groups. Turk J Pediatr Dis [Internet]. 2020 Sep. 29 [cited 2025 May 25];14(5):385-90. Available from: https://turkjpediatrdis.org/article/view/657