Abstract

Use of activated prothrombin complex concentrate (aPCC) and recombinant factor VIIa (rFVIIa) is indicated for the treatment and prophylaxis of hemophiliac patients who has developed inhibitors. rFVIIa is an off labeled drug for prophylaxis in Turkey and not covered by health insurance. In this manuscript, the efficacy and dosage for aPCC prophylaxis were evaluated. During the aPCC prophylaxis, bleeding did not occur in any of the three cases. However, two patients developed recurrent bleeding attacks after the prophylaxis ceased. Therefore, we suggest that prophylaxis by aPCC should be prolonged to prevent recurrent bleeding attacks in hemophiliacs who developed inhibitors

Keywords: Hemophilia A, inhibitory, prophylaxis

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How to cite

1.
Çulha V, Gökçebay D, Bilir ÖA, Azık M, Tavil B, Işık P, et al. PROPHYLAXIS FOR HEMOPHILIA A PATIENTS WITH INHIBITORS. Turk J Pediatr Dis [Internet]. 2012 Apr. 1 [cited 2025 May 25];6(4):245-8. Available from: https://turkjpediatrdis.org/article/view/205