Abstract
Introduction: Urinary tract infection (UTI) is a very common infection in childhood, which sometimes indicates functional or structural dysfunction in urinary tracts. If UTI is not treated properly, it may damage kidney. UTI is still one of the most common causes of chronic renal insuffi ciency in our country. The aim of this study was to investigate retrospectively the demographic, clinical and laboratory features, and prognosis of 472 patients with UTI followed up in our Pediatric Nephrology clinic. Patients and
Methods: The gender, age, symptoms, microorganisms grown in urine culture, antibiotic sensitivities, anatomic and functional abnormalities of urinary tract, and therapies given to the patients were retrospectively evaluated to determine the roles of these parameters on the development of renal damage.
Results: Among 472 patients, 368 (78%) were female and 104 (22%) were male. Of these 104 male patients, 74% were below 2 years old. Symptoms of UTI were different in various age groups. While 108 patients had only one UTI, 364 had recurrent UTI. Among all patients with UTI, 170 had risk factors of anatomic or functional urinary system abnormalities for UTI development. When these patients with risk factors and patients without risk factors were compared, the risk of UTI recurrence was not statistically signifi cant (p>0.05). The most common identifi ed microorganism was E.coli ESBL(-) and most of them (90%) were sensitive to amikacin, gentamicin, netilmicin, cefepim, ceftriaxone, ceftazidime, aztreonam and imipenem. Number of UTI recurrence showed a statistically signifi cant effect on development of renal damage (p<0.05). But there was no statistically signifi cant relationship between degree of VUR and development of renal damage (p>0.05).
Conclusion: The patients diagnosed as UTI should be investigated for urinary tract abnormalities by imaging tecniques and the ampirical antibiotics should be started to these patients according to the local antibiotic susceptibilities. As a result, early diagnosis and treatment of UTI and urinary tract abnormalities were very important for protection of the patient from long term sequelas of UTI
Keywords: Urinary tract infection, childhood
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