Abstract
Objective: To evaluate the clinical, laboratory and capillaroscopic findings of pediatric patients with Raynaud’s phenomenon.
Material and Methods: Ninety-five pediatric patients who were diagnosed with Raynaud’s phenomenon between January 2014 and January 2021, were retrospectively examined. The demographic data, laboratory parameters and capillaroscopic findings of the patients were recorded. The capillaroscopic findings of the patients were classified as normal, nonspecific abnormalities and scleroderma pattern.
Result: In this study, 469 patients with acute urticaria were evaluated. The median (min-max) age of the patients was 7 years (2 months-18 years), and 48.8 % of them were male. Angioedema was accompanying in 20 % of the patients. Recurrent acute urticaria was seen in 33.5 % (n = 157) of the patients. In the history, infections were the triggers in 37.5 % (n=176) of the patients, drugs in 17.9 % (n=84), food in 10.9 % (n=51), insect bites in 3.2 % (n=15), and 0.2 % (n=1) of them had the vaccine. When the patients were evaluated with the medical histories, physical examination and laboratory findings; triggers could not be detected in 59 % (n=276) and these patients were diagnosed as idiopathic acute urticaria. Infections (37.5 %; n=176) were in the first place in patients with triggers. Food and drug allergies were confirmed in only one patient each. Considering the etiological distribution according to age groups, it was seen that idiopathic acute urticaria was more common in the 12-18 age group and infection-associated acute urticaria in the group under 2 years old (p=0.009).
Conclusion: Mostly, triggers cannot be found in children who apply to the allergy clinic due to acute urticaria. In patients who can be identified triggers, infections are in the first place. However, patients’ clinical histories may also include food or drug(s) as a suspected trigger, and it is important to evaluate these patients with diagnostic allergy tests. Thus, misdiagnosis of patients and unnecessary food or drug restrictions would be prevented.
Keywords: Antinuclear antibody, capillaroscopy, pediatric, Raynaud’s Phenomenon, rheumatology
References
- Rigante D, Fastiggi M, Ricci F, D’Errico F, Bracci B, Guerriero C. Handy Hints About Raynaud’s Phenomenon in Children: A Critical Review. Pediatr Dermatol 2017;34:235-9.
- Goldman RD. Raynaud phenomenon in children. Can Fam Physician 2019;65:264-5.
- Turan E, Kilic SS. Retrospective view of primary Raynaud’s phenomenon in childhood. Reumatol Clín (English Edition) 2019;15:e92-e5.
- Planchon B, Pistorius M-A, Beurrier P, De Faucal P. Primary Raynaud’s phenomenon: age of onset and pathogenesis in a prospective study of 424 patients. Angiology 1994;45:677-86.
- Haque A, Hughes M. Raynaud’s phenomenon. Clin Med 2020;20:580.
- Herrick AL, Wigley FM. Raynaud’s phenomenon. Best Pract Res Clin Rheumatol 2020;34:101474.
- Esteireiro AS, Bicho A. Raynaud’s phenomenon in paediatric age. BMJ Case Rep 2020;13.
- Vicente EO, Redondo MG. Raynaud’s phenomenon in children. Reumatol Clín (English Edition) 2016;12:342-4.
- Pauling JD, Hughes M, Pope JE. Raynaud’s phenomenon—an update on diagnosis, classification and management. Clin Rheumatol 2019;38:3317-30.
- Adrovic A, Şahin S, Barut K, Kasapçopur O. Juvenile scleroderma: a referral center experience. Arch Rheumatol 2018;33:344.
- Nigrovic PA, Fuhlbrigge RC, Sundel RP. Raynaud’s phenomenon in children: a retrospective review of 123 patients. Pediatrics 2003;111:715-21.
- Pavlov‐Dolijanović S, Damjanov N, Ostojić P, Sušić G, Stojanović R, Gacić D, et al. The prognostic value of nailfold capillary changes for the development of connective tissue disease in children and adolescents with primary Raynaud phenomenon: a follow‐up study of 250 patients. Pediatr Dermatol 2006;23:437-42.
- Ingegnoli F, Herrick AL. Nailfold capillaroscopy in pediatrics. Arthritis Care Res 2013;65:1393-400.
- Petty RE, Laxer RM, Lindsley CB, Wedderburn L, Fuhlbriggezzz RC, Mellins ED. Textbook of Pediatric Rheumatology E-Book:8th ed. USA. Elsevier Health Sciences; 2020.
- Fleck DE, Hoeltzel MF. Hand and foot color change: diagnosis and management. Pediatr Rev 2017;38:511-9.
- Batu ED, Sönmez HE, Bilginer Y. Çocuklarda Raynaud Fenomeni ve Birincil ve İkincil Raynaud Hastalarının Karşılaştırılması. Turkish J Pediatr Dis 2018;12:39-43.
- Maverakis E, Patel F, Kronenberg DG, Chung L, Fiorentino D, Allanore Y, et al. International consensus criteria for the diagnosis of Raynaud’s phenomenon. J Autoimmun 2014;48:60-5.
- Schonenberg-Meinema D, Bergkamp SC, Nassar-Sheikh Rashid A, van der Aa LB, de Bree GJ, Ten Cate R, et al. Nailfold capillary abnormalities in childhood-onset systemic lupus erythematosus: a cross-sectional study compared with healthy controls. Lupus 2021;30:818-27.
- Smith V, Herrick AL, Ingegnoli F, Damjanov N, De Angelis R, Denton CP, et al. Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud’s phenomenon and systemic sclerosis. Autoimmun Rev 2020;19:102458.
- Pain CE, Constantine T, Toplak N, Moll M, Iking-Konert C, Piotto DP, et al. Raynaud’s syndrome in children: systematic review and development of recommendations for assessment and monitoring. Clin Exp Rheumatol 2016;34:200-6.
- Shapira Y, PoratKatz B-S, Gilburd B, Barzilai O, Ram M, Blank M, et al. Geographical differences in autoantibodies and anti-infectious agents antibodies among healthy adults. Clin Rev Allergy 2012;42:154-63.
- Falcini F, Rigante D, Candelli M, Martini G, Corona F, Petaccia A, et al. Anti-nuclear antibodies as predictor of outcome in a multi-center cohort of Italian children and adolescents with Raynaud’s phenomenon. Clin Rheumatol 2015;34:167-9.
Copyright and license
Copyright © 2023 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.