Abstract

Erythema multiforme (EM) is an immune-mediated condition characterized by symmetric erythematous rash with typical target lesions. Drugs, infections, immunologic conditions and food additives are among etiologic causes; but Herpes simplex virus infection is the most commonly seen reason.
We report three cases of recurrent EM associated with herpes labialis infection. They all presented with typical target lesions appearing nearly one week after the herpes labialis lesion had begun. Each patient had similar EM episodes with different frequencies. All three patients were initially treated orally with valacyclovir, then prophylactic valacyclovir with a daily dose of 500 mg for six month period.
Autoreactive T cells triggered by Herpes virus infection, are suggested to play an important role in Herpes-associated EM (HAEM) pathogenesis. The first line management of recurrent HAEM is antiviral treatments and they are generally safe and well tolerated in pediatric and general populations. Early administration of oral acyclovir or valacyclovir are recommended to reduce the severity and duration of the EM rash. Prophylactic antiviral treatment using for 6 months may be effective in controlling recurrent epizodes of HAEM. HSV infection and HAEM may recur; but prophylactic treatment may reduce the frequency and severity of epizodes.

Keywords: Children, Erythema Multiforme, Herpes Simplex Virüs

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How to cite

1.
Alim Aydın S, Metbulut AP, Dibek Mısırlıoğlu E, Metin A. Use of Valacyclovir Prophylaxis in Herpes Virus-Associated Recurrent Erythema Multiforme Cases. Turk J Pediatr Dis [Internet]. 2023 Mar. 22 [cited 2025 May 25];17(2):166-70. Available from: https://turkjpediatrdis.org/article/view/995