Abstract
Objective: We aimed to reveal newborn hearing screening test results and risk factors of babies diagnosed with congenital hypothyroidism (CH) in our hospital.
Material and Methods: The files of the newborns who were evaluated within the scope of the national newborn screening program between January and December 2019 were retrospectively reviewed. Risk factors were evaluated by comparing newborn hearing screening test results of babies with CH and euthyroid control groups.
Results: There was no significant difference between the two groups in terms of demographic and pregnancy datas. There was no significant difference between the CH and control groups in terms of the rate of failed/passed patients from the hearing screening tests. Patients with thyroid hypoplasia at CH group failed at a higher rate from the first hearing screening test.
Conclusion: In this study, there was no significant difference between CH and control groups in terms of hearing screening results.
Keywords: Newborn screening, hearing, congenital hypothyroidy
References
- 1. American Academy of Pediatrics (AAP); American Thyroid Association (ATA); Lawson Wilkins Pediatric Endocrine Society (LWPES). Update of newborn screening and therapy for congenital hypothyroidism. Pediatrics. 2006;117:2290-303.
- 2. Maciel LM, Kimura ET, Nogueira CR, Mazeto GM, Magalhães PK, Nascimento PL, et al., Congenital hypothyroidism: recommendations of the thyroid department of the Brazilian society of endocrinology and metabolism, Arq. Bras. Endocrinol. Metabol. 2013; 57: 184–92.
- 3. Özon A, Tekin N, Şıklar Z, Gülcan H, Kara C, Taştekin A et al., Gebelikte tiroid hastalıklarının neonatal etkileri ve TSH yüksekliği olan bebeğe yaklaşım: Türk Neonatoloji ve Çocuk Endokrinoloji ve Diyabet Dernekleri uzlaşı raporu. Turk Pediatri Ars 2018; 53: 209-23.
- 4. Jain V, Argawal R, Deorari AK, Paul VK. Congenital hypothyroidism. Indian J Pediatr. 2008;75:363-7.
- 5. De Andrade CLO, Machado GC, Magalhães LPF, Cerqueira TLO, Fernandes LC, Ramos HE et al., Cochlear dysfunction evidenced by reduction of amplitude of otoacustic responses in patients with congenital hypothyroidism. Int J Pediatr Otorhinolaryngol. 2019; 122: 12-7.
- 6. Ovalı P. Yenidoğan Taramaları. Klinik Tıp Pediatri Dergisi. 2019; 11: 193-9.
- 7. Arıcıgil M, Ulutaş RA, Yücel A, Arbağ H. Yenidoğan İşitme Tarama Sonuçlarımız. Selçuk Med J 2015;31: 121-3.
- 8. Li D, Henley CM, O'Malley Junior BW. Distortion product otoacoustic emissions and outer hair cell defects in the hyt/hyt mutant Mouse. Hear Res. 1999; 138: 65–72.
- 9. Mustapha M, Frang Q, Gong TW, Dolan DF, Raphael Y , Camper SA, et al., Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit 1dw mutants, J. Neurosci. 2009; 29: 1212–23.
- 10. Bellman SC, Davies A, Fuggle PW, Grant DB, Smith I. Mild impairment of neuro-otological function in early treated congenital hypothroidism. Arch Dis Child 1996; 74: 215-8.
- 11. Bruno R, Aversa T, Catena M, Valenzise M, Lombardo F, De Luca F et al., Even in the era of congenital hypothyroidism screening mild and subclinical sensorineural hearing loss remains a relatively common complication of severe congenital hypothyroidism. Hear Res. 2015; 327: 43-7.
- 12. Lichtenberger-Geslin L, Dos Santos S, Hassani Y, Ecosse E, Van Den Abbeele T, Léger J. Factors associated with hearing impairment in patients with congenital hypothyroidism treated since the neonatal period: a national population-based study. J Clin Endocrinol Metab 2013; 98: 3644-52.
- 13. Parazzini M, Ravazzani P, Medaglini S, Weber G, Fornara C, Tognola G et al., Click-evoked otoacustic emissions recorded from untreated congenital hypothyroid newborns. Hear Res. 2002; 166: 136-42.
- 14. Machado GC, Oliveira de Andrade CL, da Cruz Fernandes L, Morais de Albuquerque J, Franco Magalhães LP et al., Study of cochlear function in neonates and infants with congenital hypothyroidism. Int J Pediatr Otorhinolaryngol 2019; 124: 203-7.
