Abstract

Intraduction: The occurrence of anticardiolipin antibodies has been related to a variety of neurologic disorders including migraine in adult patients. But, their presence in pediatric population with migraine headache is uncertain. The aim of this study was to investigate the presence of anticardiolipin antibodies in children with the diagnosis of migraine headache.Patents And

Method: Twenty consecutive patients with the diagnosis of migraine were enrolled to the study (14 female; mean age 13.55±2.60). Twenty healthy subjects served as the control group (12 female; mean age 13.65±2.23). Anticardiolipin antibodies were assayed by enzymelinked immunosorbent assay (ELISA). The results were compared between the study and control groups.

Results: One of the twenty study patients showed elevated serum anticardiolipin antibody titer. This 14 years old girl had common migraine since two years and her cranial magnetic resonance imaging showed white matter hyperintensities suggesting subcortical infarcts. Serum levels of anticardiolipin antibodies in the control subjects were normal. The difference between the two groups was not statistically significant.

Conclusion: Our data overlap with the results of previous reports which did not find increased serum levels of anticardiolipin antibodies in migraine patients. On the other hand, in selected migraine patients with cranial imaging abnormalities suggesting infarcts, the evaluation of serum anticardiolipin antibodies could be of value. Studies with larger numbers of patients are warranted to determine if anticardiolipin antibodies have a specific role in pediatric migraine patients

Keywords: Anticardiolipin antibodies, migraine, childhood

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How to cite

1.
Kurul SH, Yiş U, Dirik E. THE INVESTIGATION OF SERUM ANTICARDIOLIPIN ANTIBODIES IN CHILDREN WITH THE DIAGNOSIS OF MIGRAINE HEADACHE. Turk J Pediatr Dis [Internet]. 2009 Jun. 1 [cited 2025 May 24];3(3):12-6. Available from: https://turkjpediatrdis.org/article/view/67