Abstract
Purpose: To compare the amount of basal tear secretion and tear film stability in the children with Hashimato’s Thyroiditis (HT) with healthy controls of similar age and gender distribution.Material and
Method: Thirty-eight eyes of 19 patients with HT and 38 eyes of 19 healthy controls were included in the study. Duration of HT, presence of any accompanying autoimmune disease (AAD), anti-thyroid peroxidase and anti-thyroglobulin antibody levels were noted in HT group. Presence of dry eye symptoms was asked and Schirmer and tear film break-up time (TBUT) tests were applied. Two groups were compared in terms of these parameters. The relation between the duration of HT, presence of any AAD, anti-thyroid peroxidase and anti-thyroglobulin antibody levels and Schirmer, TBUT test results were evaluated within the study group. Unpaired samples t, chi-square and rank corelation tests were used for statistical analyses.
Results: Among the 19 patients with HT, 10 had Type-1 Diabetes Mellitus (DM) and 1 had Celiac Disease. TBUT and Schirmer test results were significantly lower in the study group than controls ((t=24.56, p=0.036; t= 32.54; p=0.027, respectively). Within the study group, TBUT and Schirmer test results were significantly lower in children with an AAD than the ones without (t=11.56, p=0.042; t= 16.56; p=0.039, respectively). No relation was detected between the TBUT, Schirmer test results and the duration of HT, anti-thyroid peroxidase and anti-thyroglobulin antibody level in the study group.
Conclusion: The basal tear secretion and tear film stability are lower in children with Hashimato’s Thyroiditis, especially in the ones with accompanying autoimmune disease, than the controls
Keywords: Hashimato’s Thyroiditis, Schirmer test, tear film break-up time
References
- Wang SY, Tung YC, Tsai WY, Lee IS, Hsiao PH.Long-term out- come of hormonal status in Taiwanese children with Hashimoto’s thyroiditis. Eur J Pediatr 2006;165:481-483.
- Biro E, Szekanecz Z, Czirjak L, Dankó K, Kiss E, Szabó NA, Szucs G, Zeher M, Bodolay E, Szegedi G, Bakó G. Association of systemic and thyroid autoimmune diseases. Clin Rheumatol ;25:240-245. Lorini R, Gastaldi R, Traggiai C,Perucchin PP. Hashimoto’s Thyroiditis. Pediatr Endocrinol Rev 2003;2:205-211.
- Muratani H, Nakashima T, Ueno M,Sato H, Inove K, Shiraki Y. Pseudoxanthoma elasticum associated with Hashimoto’s thyroidi- tis. Jpn J Med 1982;21:223-226.
- Reyniers R, Paridaens D. Spontaneous globe luxation and floppy eyelid syndrome in a patient with Hashimoto’s disease. Eye ;21:303-304. Moss SE, Klein R, Klein BE. Prevalence of and risk factors for dry eye syndrome. Arch Ophthalmol 2000;118:1264-1268.
- Kaiserman I, Kaiserman N, Nakar S, Vinker S. Dry eye in diabetic patients. Am J Ophthalmol 2005;139:498-503.
- Eckstein AK, Finkenrath A, Heiligenhaus A, Renzing-Köhler K, Esser J, Krüger C, Quadbeck B, Steuhl KP, Gieseler RK. Dry eye syndrome in thyroid-associated ophthalmopathy: lacrimal expres- sion of TSH receptor suggests involvement of TSHR-specific autoantibodies. Acta Ophthalmol Scand 2004;82:291-297.
- Fox RI. Sjögren’s Syndrome. Curr Opin Rheumatol 1995;7:409
- Barsouk A, Peele KA, Kiljanski J, Stolarski C, Nebes V, Kenner- dell JS, Volpe R, Wall JR. Antibody-dependent cell-mediated cyto- toxicity against orbital target cells in thyroid-associated ophthal- mopathy and related disorders; close relationship between serum cytotoxic antibodies and parameters of eye muscle dysfunction. J Endocrinol Invest 1996;19:334-341.
