Ülkemizde Çocuklarda İki Farklı Zaman Diliminde İzlenen Akut Bakteriyel Menenjitlerin Değerlendirilmesi

Aysun Kara Uzun; Aysel Yöney; Benal Kunak; Saliha Kanık Yüksek; Hasan Tezer

Research Article

Turk J Pediatr Dis 2018; 12(3): 193-199.

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Evaluation of Children with Acute Bacterial Meningitis Treated in Two Separate Time Periods in Turkey

Authors

Aysun Kara Uzun

Aysel Yöney

Benal Kunak

Saliha Kanık Yüksek

Hasan Tezer

Affiliations

Turk J Pediatr Dis 2018; 12(3): 193-199.

Published: December 1, 2018

Abstract

Objective: Bacterial meningitis is a medical emergency. The mortality rate in untreated bacterial meningitis is 100%. The aim of the present study was to determine the changes in acute bacterial meningitis epidemiology, treatment options and complication rates in Turkey over the years by evaluating acute bacterial meningitis treated in two different centers before and after the introduction of the conjugate vaccines against Haemophilus influenzae type b and Streptococcus pneumoniae into the National Immunization Program in Turkey.

Material and Methods: The study is a retrospective study. The study included 54 patients who were followed up for the diagnosis of acute bacterial meningitis at the Infectious Diseases Clinic of University of Health Sciences, Ankara Doctor Sami Ulus Children and Gynecology-Obstetrics Training and Research Hospital (first center) between September 1, 1995 and July 31, 1996 and 17 patients who were followed up with the same diagnosis at the Infectious Disease Clinic of University of Health Sciences, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital (second center) between February 1, 2012 and March 16, 2016. Bacterial meningitis diagnosis was done according to the World Health Organization criteria

Keywords: Vaccine, Bacterial meningitis, Children, Complication

References

Silva WA, Pinheiro AM, Coutinho LG, Marinho LAC, Lima LFA. Epidemiological profile of acute bacterial meningitis in the State of Rio Grande do Norte, Brazil. Rev Soc Bras Med Trop 2010 43:455- 7.
millipediatri.org.tr/Uploads/EditorImages/files/asilama.pdf. Erişim tarihi: 12 Temmuz 2016.
World Health Organisation. Vaccine research and development. Generic protocol for population-based surveillance of Haemophilus influenzae type B. Geneva, 1996. (http://www.who. int/vaccines- documents/DocsPDF/www9723.pdf).
van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004; 351:1849-59.
Roca A, Bassat Q, Morais L, Machevo S, Sigaşque B, O’Callaghan C, et al. Surveillance of acute bacterial meningitis among children admitted to a district hospital in rural Mozambique. Clin Infect Dis 2009; 48:172-80.
Mani R, Pradhan S, Nagarathna S, Wasiulla R, Chandramuki A. Bacteriological profile of community acquired bacterial meningitis: A ten-year retrospective study in a tertiary neurocare centre in South India. Indian J Med Microbiol 2007;25:108-14.
Thigpen MC, Whitney CG, Messonnier NE, Zell ER, Lynfield R, Hadler JL, et al. Bacterial meningitis in the United States, 1998- 2007. N Engl J Med 2011;364:2016-25.
Uysal G, Güven A, Köse G, Yüksel G, Yüksel S, Oskovi H. Çocukluk çağında akut bakteriyel menenjitlerde etyolojik ajanlar, klinik tablo ve prognoz. T Klin Pediatri 2001;10:93-8.
American Academy of Pediatrics. Pneumococcal infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS (eds). Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed. Elk Grove Village, IL: American Academy of Pediatrics, 2015:626.
American Academy of Pediatrics. Meningococcal infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS (eds). Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed. Elk Grove Village, IL: American Academy of Pediatrics, 2015:547.
American Academy of Pediatrics. Haemophilus influenzae infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS (eds). Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed. Elk Grove Village, IL:American Academy of Pediatrics, 2015:368.
Baraff LJ, Lee SI, Schriger DL. Outcomes of bacterial meningitis in children: A meta-analysis. Pediatr Infect Dis J 1993;12:389-94.
Anderson V, Anderson P, Grimwood K, Nolan T. Cognitive and executive function 12 years after childhood bacterial meningitis: Effect of acute neurologic complications and age of onset. J Pediatr Psychol 2004;29:67-81.
Koomen I, Grobbee DE, Roord JJ, Donders R, Jennekens-Schinkel A, van Furth AM. Hearing loss at school age in survivors of bacterial meningitis: Assessment, incidence, and prediction. Pediatrics 2003;112:1049-53.
Pomeroy SL, Holmes SJ, Dodge PR, Feigin RD. Seizures and other neurologic sequelae of bacterial meningitis in children. N Engl J Med 1990;323:1651-7.
Grimwood K, Anderson P, Anderson V, Tan L, Nolan T. Twelve year outcomes following bacterial meningitis: Further evidence for persisting effects. Arch Dis Child 2000;83:111-6.
Saez-Llorens X, McCracken GH Jr. Acute bacterial meningitis beyond the neonatal period. In: Long SS, Pickering LK, Prober CG (eds). Principles and Practice of Pediatric Infectious Diseases. 3rd ed. Philadelphia: Churchill Livingstone Elsevier, 2008:284-91.
Taylor HG, Schatschneider C, Minich NM. Longitudinal outcomes of Haemophilus influenzae meningitis in school-age children. Neuropsychology 2000;14:509-18. 78:959-82.

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How to cite

Uzun AK, Yöney A, Kunak B, Yüksek SK, Tezer H. Evaluation of Children with Acute Bacterial Meningitis Treated in Two Separate Time Periods in Turkey. Turk J Pediatr Dis [Internet]. 2018 Dec. 1 [cited 2025 May 24];12(3):193-9. Available from: https://turkjpediatrdis.org/article/view/510

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[ref1] Silva WA, Pinheiro AM, Coutinho LG, Marinho LAC, Lima LFA. Epidemiological profile of acute bacterial meningitis in the State of Rio Grande do Norte, Brazil. Rev Soc Bras Med Trop 2010 43:455- 7.

[ref2] millipediatri.org.tr/Uploads/EditorImages/files/asilama.pdf. Erişim tarihi: 12 Temmuz 2016.

[ref3] World Health Organisation. Vaccine research and development. Generic protocol for population-based surveillance of Haemophilus influenzae type B. Geneva, 1996. (http://www.who. int/vaccines- documents/DocsPDF/www9723.pdf).

[ref4] van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma JB, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med 2004; 351:1849-59.

[ref5] Roca A, Bassat Q, Morais L, Machevo S, Sigaşque B, O’Callaghan C, et al. Surveillance of acute bacterial meningitis among children admitted to a district hospital in rural Mozambique. Clin Infect Dis 2009; 48:172-80.

[ref6] Mani R, Pradhan S, Nagarathna S, Wasiulla R, Chandramuki A. Bacteriological profile of community acquired bacterial meningitis: A ten-year retrospective study in a tertiary neurocare centre in South India. Indian J Med Microbiol 2007;25:108-14.

[ref7] Thigpen MC, Whitney CG, Messonnier NE, Zell ER, Lynfield R, Hadler JL, et al. Bacterial meningitis in the United States, 1998- 2007. N Engl J Med 2011;364:2016-25.

[ref8] Uysal G, Güven A, Köse G, Yüksel G, Yüksel S, Oskovi H. Çocukluk çağında akut bakteriyel menenjitlerde etyolojik ajanlar, klinik tablo ve prognoz. T Klin Pediatri 2001;10:93-8.

[ref9] American Academy of Pediatrics. Pneumococcal infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS (eds). Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed. Elk Grove Village, IL: American Academy of Pediatrics, 2015:626.

[ref10] American Academy of Pediatrics. Meningococcal infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS (eds). Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed. Elk Grove Village, IL: American Academy of Pediatrics, 2015:547.

[ref11] American Academy of Pediatrics. Haemophilus influenzae infections. In: Kimberlin DW, Brady MT, Jackson MA, Long SS (eds). Red Book: 2015 Report of the Committee on Infectious Diseases, 30th ed. Elk Grove Village, IL:American Academy of Pediatrics, 2015:368.

[ref12] Baraff LJ, Lee SI, Schriger DL. Outcomes of bacterial meningitis in children: A meta-analysis. Pediatr Infect Dis J 1993;12:389-94.

[ref13] Anderson V, Anderson P, Grimwood K, Nolan T. Cognitive and executive function 12 years after childhood bacterial meningitis: Effect of acute neurologic complications and age of onset. J Pediatr Psychol 2004;29:67-81.

[ref14] Koomen I, Grobbee DE, Roord JJ, Donders R, Jennekens-Schinkel A, van Furth AM. Hearing loss at school age in survivors of bacterial meningitis: Assessment, incidence, and prediction. Pediatrics 2003;112:1049-53.

[ref15] Pomeroy SL, Holmes SJ, Dodge PR, Feigin RD. Seizures and other neurologic sequelae of bacterial meningitis in children. N Engl J Med 1990;323:1651-7.

[ref16] Grimwood K, Anderson P, Anderson V, Tan L, Nolan T. Twelve year outcomes following bacterial meningitis: Further evidence for persisting effects. Arch Dis Child 2000;83:111-6.

[ref17] Saez-Llorens X, McCracken GH Jr. Acute bacterial meningitis beyond the neonatal period. In: Long SS, Pickering LK, Prober CG (eds). Principles and Practice of Pediatric Infectious Diseases. 3rd ed. Philadelphia: Churchill Livingstone Elsevier, 2008:284-91.