Moyamoya disease (MMD) is a cerebrovascular condition that predisposes affected patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches. Moyamoya disease has been described in association with a variety of congenital and acquired diseases. Some congenital hematological diseases (Fanconi anemia, sickle cell anemia), genetic syndromes (Apert’s syndrome, Seckel syndrome, Robinow syndrome, Down syndrome, neurofibromatosis type I), metabolic diseases (homocystinuria) are known to associated with Moyamoya syndrome. It is also known that MMD may develop after cranial radiotherapy in children with sella/ chiasma region tumors or after prophylactic cranial irradiation for leukemia. However, there is no data regarding the presence of an association between ovarian tumor and MMD. Here, we report a case of an 8-year-old girl with recurrent ovarian tumor developed MMD after salvage chemotherapy.

Keywords: Cancer, Germ cell tumor, Moyamoya disease, Ovarian tumor, Vasculopathy