Abstract
The coronavirus pandemic has emerged as one of the most significant global health crises, affecting people worldwide and resulting in the loss of millions of lives. It was officially named “Coronavirus disease 2019” (COVID-19) when it first appeared at the end of 2019. Multisystem Inflammatory Syndrome in Children (MIS-C) is a relatively new disease entity that has arisen in the wake of the COVID-19 pandemic. While MIS-C is recognized to manifest with various symptoms, our understanding of it continues to evolve as more articles and case reports are published in the scientific literature. Although MIS-C affects multiple organ systems, there have also been reported cases of neurological involvement. According to the literature, cases of hemiparesis without imaging findings in MIS-C have rarely been reported. To the best of our knowledge, this is a rare reported case of hemiparesis without intracranial and spinal pathology in the context of MIS-C reported in this article.
Keywords: acute hemiparesis, child, COVID-19, MIS-C, neurologic manifestation
References
- Martins MM, Prata-Barbosa A, Ledo Alves da Cunha AJ. Update on SARS-CoV-2 infection in children. Paediatrics and International Child Health 2021;41;56-64.
- Panigrahy N, Policarpio J, Ramanathan R. Multisystem inflammatory syndrome in children and SARS-CoV-2: A scoping review. Pediatr Rehabil Med 2020;13:301-16.
- Loke Y-HY-H, Berul CICI, Harahsheh ASAS. Multisystem inflammatory syndrome in children: is there a linkage to Kawasaki disease? Trends Cardiovasc Med 2020; 30: 389–96.
- Information for Healthcare Providers about Multisystem Inflammatory Syndrome in Children (MIS-C) | CDC. Full text: https://www.cdc.gov/mis-c/hcp/ (accessed 12 August 2020).
- Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet 2020; 395: 1607–8.
- Licciardi F, Pruccoli G, Denina M, Parodi E, Taglietto M, Rosati S, et al. SARS-CoV-2-Induced Kawasaki-Like Hyperinflammatory Syndrome: A Novel COVID Phenotype in Children. Pediatrics 2020;146: e20201711.
- Romero-Sánchez CM, Díaz-Maroto I, Fernández-Díaz E. Neurologic manifestations in hospitalized patients with COVID-19: The ALBACOVID registry. Neurology 2020;95:1060-70.
- Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol 2020;77:683-90.
- Panda PK, Sharawat IK, Panda P, Natarajan V, Bhakat R, Dawman L. Neurological Complications of SARS-CoV-2 Infection in Children: A Systematic Review and Meta-Analysis. J Trop Pediatr 20201; 67:fmaa070.
- Susanna Esposito, Nicola Principi. Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2. Pediatric Drugs 2021;23:119–29.
- Dufort EM, Koumans EH, Chow EJ, Rosenthal EM, Muse A, Rowlands J, et al. Multisystem Inflammatory Syndrome in Children in New York State. N Engl J Med 2020;383:347-58.
- Whittaker E, Bamford A, Kenny J, Kaforou M, Jones CE, Shah P, et al. Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2. JAMA 2020;324:259-69.
- Kaushik A, Gupta S, Sood M, Sharman S, Verma S. A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection. Pediatr Infect Dis J 2020;39:340-6.
- Radia T, Williams N, Agrawal P, Harman K, Weale J, Cook J, et al. A. Multi-system inflammatory syndrome in children&adolescents (MIS-C): A systematic review of clinical features and presentation. Paediatr Respir Rev 2020;38: 51-7.
- Cirks BT, Rowe SJ, Jiang SY, Brooks R, Mulreany MP, Hoffner W, et al. 16 Weeks Later: Expanding the Risk Period for MIS-C. J Pediatric Infect Dis Soc 2021;10: 686–90.
- Abdel-Mannan O, Eyre M, Löbel U, Bamford A, Eltze C, Hameed B, et al. Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children. JAMA Neurol 2020;77:1440-5.
- LaRovere KL, Riggs BJ, Poussaint TY, Yonug CC, Newhams MM, Maamari M, et al. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol 2021;78:536-47.
- Sa M, Mirza L, Carter M, Carlton Jones L, Gowda V, Handforth J, et al. Study Group. Systemic Inflammation Is Associated With Neurologic Involvement in Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2. Neurol Neuroimmunol Neuroinflamm 2021 13;8:e999.
- Chinnabhandar V, Singh A, Mandal A, Parmar BJ. Acute Hemiplegia in Children: A Prospective Study of Etiology, Clinical Presentation, and Outcome from Western India. J Neurosci Rural Pract 2018;9:504-9.
- Nandyala A, Shah T, Ailani J. Hemiplegic Migraine. Curr Neurol Neurosci Rep 2023 ;23:381-7.
Copyright and license
Copyright © 2024 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.