Abstract
Acrodermatitis enteropathica is a rare disorder caused by zinc deficiency. The classic triad of symptoms includes perioral dermatitis, diarrhea, and alopecia. A rare cause of the acquired form is zinc deficiency due to total parenteral nutrition. Diagnosis can be challenging due to nonspecific symptoms. This paper presents a case of acrodermatitis enteropathica in a 5-month-old infant who had been on total parenteral nutrition since birth. Unlike the literature, the patient’s clinical improvement was observed with zinc spray and zinc cream treatment.
Keywords: Acrodermatitis enteropathica, Zinc deficiency, Zinc spray
References
- Glutsch V, Hamm H, Goebeler M. Zinc and skin: an update. J Dtsch Dermatol Ges 2019;17:589-96.
- Saper RB, Rash R. Zinc: an essential micronutrient. Am Fam Physician 2009;79:768-72.
- Baruch D, Naga L, Driscoll M, Kao G. Acrodermatitis enteropathica from zinc-deficient total parenteral nutrition. Cutis 2018;101:450-3.
- Wiznia LE, Bhansali S, Brinster N, Al-Qaqaa YM, Orlow SJ, Oza V. Acquired acrodermatitis enteropathica due to zinc-depleted parenteral nutrition. Pediatr Dermatol 2019;36:520-3.
- Maverakis E, Fung MA, Lynch PJ, Draznin M, Michael DJ, Ruben B, et al. Acrodermatitis enteropathica and an overview of zinc metabolism. J Am Acad Dermatol 2007;56:116-24.
- D’Amico G, De Laet C, Smits G, Salik D, Deprez G, Vilain C, et al. Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant. Pediatr Rep 2021;13:444-9.
- Alwadany MM, Al Wadani AF, Almarri FH, Alyami HS, Al-Subaie MA. Acrodermatitis Enteropathica: A Rare Case with Lifelong Implications. Cureus 2023;15:e37783.
- Cleminson K, Hull PR, Price E, Green PJ. Acute onset of blisters in an infant with acrodermatitis enteropathica: A case report. SAGE Open Med Case Rep 2021;9:2050313X20984119.
- Önder S, Erdem H, Dere G. An Acrodermatitis Enteropathica Case. Van Med J2019; 26: 261-4.
- Proli F, Margiotta G, Ferretti S, Drosi A, Valentini P, Buonsenso D, et al. Acrodermatitis enteropathica during parenteral nutrition: a pediatric case report. Acta Biomed 2023;94:e2023180.
- Ciampo IRLD, Sawamura R, Ciampo LAD, Fernandes MIM. Acrodermatitis Enteropathica: Clinical Manifestations and Pediatric Diagnosis. Rev Paul Pediatr 2018;36:238-41.
- Okhovat JP, O’Leary R, Hu M, Zussman J, Binder S, Worswick S. Acrodermatitis enteropathica in a patient with short bowel syndrome. Cutis 2017;100: E4-E6.
Copyright and license
Copyright © 2024 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.