Öz
“Drug Induced Hypersensitivity Syndrome” (DiHS) ya da diğer adı ile “Drug Rash with Eoshinophilia and Systemic Symptoms” (DRESS) sendromu, yaşamı tehdit edebilen gecikmiş tip ilaç hipersensitivite reaksiyonudur. Ateş, deri döküntüsü, lenfadenopati, hematolojik anormallikler ve çoklu organ tutulumu ile karakterizedir. Karaciğer en sık tutulan organ olup, çoğunlukla karaciğer enzim yüksekliği ve akut anikterik hepatit şeklinde karşımıza çıkmaktadır. Çok daha nadir olarak kolestaz eşlik edebilir ve bu durum kötü prognoza işaret etmektedir. Bu yazıda valproik asit ilişkili hepatik yetmezlik ve ağır kolestazın görüldüğü DRESS sendromlu bir olgu sunulmuştur. İlaç kullanımı ile semptomların başlangıcı arasındaki sürenin uzun olması ve semptomların çeşitliliği nedeniyle DRESS sendromunun tanısında gecikmeler olabilmektedir. Hastalığın erken tanınması, morbidite ve mortaliteyi azaltmak açısından oldukça önem taşımaktadır.
Anahtar Kelimeler: Drug Induced Hypersensitivity Syndrome (DiHS), ilaç alerjisi, hepatik yetmezlik, DRESS
Referanslar
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