Öz
Amaç: Hipertansiyon patogenezinde diyetle aşırı sodyum ve düşük potasyum alımının ilişkisinin araştırılması.
Gereç ve Yöntemler: Çalışmaya 6-18 yaş arasında 56 obez normotansif, 41 obez hipertansif hasta ve kontrol grubu
olarak 29 sağlıklı çocuk çalışmaya dahil edilmiştir. Öğleden sonraki idrar örneklerinde sodyum/potasyum oranı ve Tanitabiyoempedans
yöntemi ile ayrıca total vücut yağ oranları değerlendirilmiştir.
Bulgular: Hipertansif 41 obez hastanın 10’u ≤10 yaş iken 31’i > 10 yaş olarak bulundu.
İnsülin düzeyleri ve HOMA-IR indeksleri, obez normotansif ve hipertansif gruplarda sırasıyla16.7±8.3ve 15.9±7.9 U/
ml, 4.4±3.4 ve5.3±3.4 olarak bulundu, istatistiksel olarak anlamlı fark saptanmadı. İdrar Na, K, Na/K ve mikroalbumin/
kreatinin oranlarında da kontrol, OHT ve ONT grupları arasında istatistiksel olarak anlamlı farklılık bulunmadı.
Sonuç: Artmış tuzlu ve yağlı yiyecek tüketimi, sedanter yaşam, hipertansiyon ve ilişkili hastalıklar açısından neden olabilecek
faktörlerdendir.
Anahtar Kelimeler: Hipertansiyon, Obezite, İdrar Na/K
Kaynakça
- Kotchen TA. Obesity-related hypertension: Epidemiology, pathophysiology, and clinical management. Am J Hypertens 2010;23:1170-8.
- Lee S-G, Lee W, Kwon OH, Kim JH. Association of urinary sodium/creatinine ratio and urinary sodium/specific gravity unit ratio with blood pressure and hypertension: KHANES 2009-2010. Clinica Chimica Acta 2013;424:168-73.
- Thuesen B, Toft U, Buhelt L, Linneber A, Friedrich N, Nauck M, et al. Estimated daily salt intake in relation to blood pressure and blood lipids: the role of obesity. European Journal of Preventive Cardiology 2015;22:1567-74.
- Geleijnse JM, Grobbee DE, Hofman A. Sodium and potassium intake and blood pressure change in childhood. BMJ 1990;300:899-902.
- Bundak R, Furman A, Gunoz H, Darendeliler F, Bas F, Neyzi O. Body mass index references for Turkish children. Acta Paediatr 2006;95:194-8.
- Montague CT, O’Rahilly S. The perils of portliness: Causes and consequences of visceral adiposity. Diabetes 2000;49:883–8.
- Reinehr T, Kiess W, Kapellen T, Andler W. Insulin sensitivity among obese children and adolescents, according to degree of weight loss. Pediatrics 2004; 114:1569-73.
- Reinehr T, Andler W. Changes in the atherogenic risk factor profile according to degree of weight loss. Arch Dis Child 2004;89:419–22.
- Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362-74.
- Kurtoğlu S, Hatipoğlu N, Mazıcıoğlu M, Kendirici M, Keskin M, Kondolot M. Insulin resistance in obese children and adolescents: HOMA-IR cut-off levels in the prepubertal and pubertal periods. J Clin Res Ped Endo 2010;2:100-6.
- National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555-76.
- Urbina E, Alpert B, Flynn J, Hayman L, Harshfield GA, Jacobson M, et al. American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee. Ambulatory blood pressure monitoring in children and adolescents: recommendations for standard assessment: A scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in Youth Committee of the council on cardiovascular disease in the young and the council for high blood pressure research. Hypertension 2008;52:433–51.
- Strojny W, Drozdz D, Fijorek K, Korostynski M, Piechota M, Balwierz W, et al. Looking for new diagnostic tools and biomarkers of hypertension in obese pediatric patients. Blood Press Monit 2017;22:122-30.
- Elliott P, Stamler J, Nichols R, Dyer AR, Stamler R, Kesteloot H, et al. Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations. Intersalt Cooperative Research Group. BMJ 1996;312:1249–53.
- Intersalt Cooperative Research Group. Intersalt: An international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. BMJ 1988;297:319–28.
- Engeli S, Bohnke J, Gorzelniak K, Janke J, Schling P, Bader M, et al. Weight loss and the renin-angiotensin-aldosterone system. Hypertension 2005;45:356–62.
- Bogaert YE, Linas S. The role of obesity in the pathogenesis of hypertension. Nat Clin Pract Nephrol 2009;5:101–11.
- DeFronzo RA. Insulin and renal sodium handling: clinical implications. Int J Obes 1981;5 (Suppl 1): 93–104.
- Adrogue ́ HJ, Madias NE. Sodium and potassium in the pathogenesis of hypertension. N Engl J Med 2007;356:1966–78.
- Buendia JR, Bradlee ML, Daniels SR, Singer MR, Moore LL. Longitudinal effects of dietary sodium and potassium on blood pressure in adolescent girls. JAMA Pediatr 2015;169:560-8.
- Janghorbani M, Aminorroaya A, Amini M. Comparison of different obesity indices for predicting incident hypertension. High Blood Press Cardiovasc Prev 2017;24:157-66.
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