Öz
Sitomegalovirüs en sık konjenital enfeksiyon yapan etkendir. Gebeliğin erken döneminde enfekte olan fetusların %10- 15’i doğumda semptomatik olup, olgularda intrauterin büyüme kısıtlanması, hepatosplenomegali, kolestaz, karaciğer fonksiyon testlerinde bozulma, pnömoni, pansitopeni, hemolitik anemi, peteşi, purpura, dermal eritropoez ve santral sinir sistemi bulgularının belirgin olduğu ağır sistemik hastalık tablosu görülmektedir. Konjenital CMV enfeksiyonunda santral sinir sitemine ait bulgular oldukça çeşitli olup nöronal migrasyon anomalileri nadiren tespit edilmektedir. Burada ağır nöronal migrasyon anomalisinin ön planda olduğu konjenital sitomegalovirüs enfeksiyonu olan bir prematüre yenidoğan olgusu sunulmaktadır.
Anahtar Kelimeler: Nöronal migrasyon anomalileri, Prematüre, Sitomegalovirüs, Yenidoğan
Referanslar
- Leruez-Ville M, Ville Y. Fetal cytomegalovirus infection. Best Pract Res Clin Obstet Gynaecol 2017;38:97-107.
- Manara R, Balao L, Baracchini C, Drigo P, D'Elia R, Ruga EM. Brain magnetic resonance findings in symptomatic congenital cytomegalovirus infection. Pediatric Radiology 2011;41:962-70.
- Boppana SB, Pass RF, Britt WJ, Stagno S, Alford CA. Symptomatic congenital cytomegalovirus infection: Neonatal morbidity and mortality. Pediatr Infect Dis J 1992;11:93-9.
- Rivera LB, Boppana SB, Fowler KB, Britt WJ, Stagno S, Pass RF. Predictors of hearing loss in children with symptomatic congenital cytomegalovirus infection. Pediatrics 2002;110:762-7.
- Turner KM, Lee HC, Boppana SB, Carlo WA, Randolph DA. Incidence and impact of CMV infection in very low birth weight infants. Pediatrics 2014;133:e609-15.
- Averill LW, Kandula VV, Akyol Y, Epelman M. Fetal brain magnetic resonance imaging findings in congenital cytomegalovirus infection with postnatal imaging correlation. Semin Ultrasound CT MR 2015;36:476-86.
- Capretti MG, Lanari M, Tani G, Ancora G, Sciutti R, Marsico C, et al. Role of cerebral ultrasound and magnetic resonance imaging in newborns with congenital cytomegalovirus infection. Brain Dev 2014;36:203-11.
- Gabrielli L, Bonasoni MP, Santini D, Piccirilli G, Chiereghin A, Petrisli E, et al. Congenital cytomegalovirus infection: Patterns of fetal brain damage. Clin Microbiol Infect 2012;18:E419–E27.
- Dogan Y, Yuksel A, Kalelioglu IH, Has R, Tatli B, Yildirim A. Intracranial ultrasound abnormalities and fetal cytomegalovirus infection: Report of 8 cases and review of the literature. Fetal Diagn Ther 2011;30:141-9.
- Oosterom N, Nijman J, Gunkel J, Wolfs TF, Groenendaal F, Verboon-Maciolek MA, et al. Neuro-imaging findings in infants with congenital cytomegalovirus infection: Relation to trimester of infection. Neonatology 2015;107:289-96.
- Satılmış A, Güre A, Ongun H, Mendilcioğlu İ, Çolak D, Oygür N. CMV seroconversion in pregnants and the incidence of congenital CMV infection. Turk J Pediatr 2007;49:30-6.
