Öz

Amaç: Bu çalışmanın amacı, solunum yolu enfeksiyonlarına neden olan beş yaygın viral etkenin—influenza virüsü (IFV), insan respiratuvar sinsityal virüsü (hRSV), insan rinovirüsü (hRV), insan metapnömovirüsü (hMPV) ve insan bokavirüsü (hBoV)—altta yatan kronik hastalığı olmayan çocuklardaki laboratuvar parametreleri ve klinik sonuçlar üzerindeki etkilerini karşılaştırmalı olarak araştırmaktır.

Gereç ve Yöntem: Ocak 2020 ile Aralık 2024 tarihleri arasında Ankara Bilkent Şehir Hastanesi’ne başvuran, bir ay ile on sekiz yaş arasındaki çocuk hastalar retrospektif olarak değerlendirildi. Çalışmaya yalnızca tek bir viral etken tespit edilen ve hastaneye yatırılan çocuklar dahil edildi. Tanımlanan viral patojenlere göre klinik veriler ve laboratuvar parametreleri analiz edildi.

Bulgular: Çalışmaya dahil edilen 983 hastanın %62’si erkekti. En sık tespit edilen viral etken IFV olurken, bunu sırasıyla hBoV, hRSV, hRV ve hMPV izledi. IFV enfeksiyonlarında AST ve ALT düzeylerinde yükselme gözlendi. hRSV enfeksiyonlarında PCO₂ ve HCO₃ parsiyel basınçlarında anlamlı artışlar tespit edildi. hBoV enfeksiyonlarında ise CRP, lökosit (WBC) ve nötrofil/lenfosit oranı (NLR) gibi inflamatuar belirteçler en yüksek seviyelere ulaştı. Ayrıca, pH düzeyinde azalma ve PCO₂ düzeyinde artış, entübasyon ve yoğun bakım ihtiyacı ile anlamlı şekilde ilişkili bulundu.

Sonuç: Farklı viral etkenlerin sergilediği özgün biyobelirteç profilleri, klinik karar sürecine rehberlik edebilir. Özellikle LDH, pH, PCO₂ ve CRP gibi belirteçlerin hastaneye yatış sırasında erken değerlendirilmesi, hastalığın şiddetini öngörmede ve yoğun bakım gereksiniminin belirlenmesinde değerli olabilir.

Anahtar Kelimeler: İnsan bocavirüsü, İnsan metapnömovirüsü, İnsan solunum sinsityal virüsü, İnsan rinovirüsü, İnfluenza virüsü, Alt solunum yolu enfeksiyonları

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Telif hakkı ve lisans

Nasıl atıf yapılır

1.
Kalaycı F, Çelebier K. Yaygın Solunum Virüslerinin Hastaneye Yatırılan Çocuklardaki Farklı Laboratuvar Bulguları: Retrospektif Bir Çalışma. Turk J Pediatr Dis [Internet]. 2025 May 14 [cited 2025 May 24];19(3):130-6. Available from: https://turkjpediatrdis.org/article/view/1090