Abstract

Background and aim: Familial Mediterranean Fever (FMF) is a hereditary multi-systemic disease that is frequent in Turkey. Our aim is to determine the frequency of hypercalciuria and the risk of urinary stone disease in children with FMF. Materials and methods: In our study twenty-three children with acute phase FMF disease and 58 children with remission phase FMF disease were included. They are diagnosed by anamnesis, clinical and molecular genetic studies. 25 age- and gender-matched healthy control children were included. Acute phase reaction was defined by increased acute phase reactants (AFR) including erythrocyte sedimentation rate, C-reactive protein and fibrinogen levels.

Results: Children with acute phase FMF had higher AFR levels when compared with both remission phase and the control subjects (P<0.001 for each). However, no difference was found in AFR levels between remission phase FMF and the control subjects (P>0.05). Urinary daily calcium excretion was higher during acute attack (4.63±1.75 mg/kg/day) than those of both remission phase (3.88±0.97 mg/kg/day) and the control group (3.30±0.82 mg/kg/day). However the difference reached to a significant level between acute attack phase and the control subjects (P=0.013). The frequency of hypercalciuria was 30% in acute phase, 26% in remission phase and 4.5% in control subjects.

Conclusions: High urinary calcium excretion of FMF children should be taken into account considering elevated urinary calcium as a metabolic risk factor for urinary stone formation

Keywords: Children, FMF, urinary stone disease, hypercalciuria

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How to cite

1.
Evliyaoğlu O, Bozkurt Y, Kelekçi S, Tutanç M, Yel S. URINARY CALCIUM EXCRETION IN CHILDREN WITH FAMILIAL MEDITERRANEAN FEVER. Turk J Pediatr Dis [Internet]. 2009 Aug. 1 [cited 2025 May 24];3(2):28-34. Available from: https://turkjpediatrdis.org/article/view/60