Bakteriyel Enfeksiyon Tanısında Eozinopeni Varlığının Önemi

Gül İrem Kanberoğlu; Özlem Bağ; Utku Karaarslan; Serpil Ece Aras Öztürk; Çiğdem Ecevit; Serpil Ece Aras Öztürk

Research Article

Turk J Pediatr Dis 2015; 9(4): 239-242.

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The Importance of the Presence of Eosinopenia in the Diagnosis of Bacterial Infection

Authors

Gül İrem Kanberoğlu

Özlem Bağ

Utku Karaarslan

Serpil Ece Aras Öztürk

Çiğdem Ecevit

Serpil Ece Aras Öztürk

Affiliations

Turk J Pediatr Dis 2015; 9(4): 239-242.

Published: December 1, 2015

Abstract

Objective: The relationship between eosinopenia and infection was previously described, but is still not fully elucidated. The aim of this study was to determine the diagnostic value of eosinophil counts in patients with bacterial infection.

Material and Methods: We compared white blood cell count, absolute neutrophil count, C-reactive protein, and absolute eosinophil count values of 55 inpatients at Izmir Dr. Behçet Uz Children’s Diseases and Surgery Training and Research Hospital between January 2013 and March 2014 who had bacterial growth in blood, urine or other (abscess, sputum, gaita, thoracentesis fluid, joint fluid) cultures with the control group.results: The white blood cell count, absolute neutrophil count and C-reactive protein values in children with bacterial infection were significantly higher than in healthy children, while the absolute eosinophil count was lower. ROC analysis revealed that the absolute eosinophil count had the highest sensitivity in differentiating bacterial infection compared to the other parameters.conclusion: Absolute eosinophil count has been shown to have the highest sensitivity compared to other parameters in the differentiation of bacterial infections. An absolute eosinophil count below 100/mm³ can be a useful marker in the diagnosis of bacterial infection

Keywords: Bacterial infections, Child, Eosinophils

References

Hoffman, Hematology Basic Principles and practice. 3rd ed, Churchill Livingstone 2000.
Zappert J. Ueberdas Vorkommen der Eosinophilen Zellen in menschlichen Blute. Z Klin Med 1893;23:227-308.
Simon CE. A manual of clinical diagnosis. London. Henry Klimpton 1922:53.
Aygun G. Sepsis tanısı. İçinde: Guncel bilgiler ışığında sepsis. İ.U. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri Sempozyum Dizisi. No: 51. İstanbul: 2006:51-60.
Rey C, Los Arcos M, Concha A, Medina A, Prieto S, Martinez P, Prieto B. Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children. Intensive Care Med 2007;33:477-84.
Devrim İ, Secmeer G. Prokalsitoninin çocukluk döneminde kullanımı. Hacettepe Tıp Dergisi 2006;37:217-22.
Jensen JU, Heslet L, Jensen TH, Espersen K, Steffensen P, Tvede M. Procalcitonin increase in early identification of critically ill patients at high risk of mortality. Crit Care Med 2006;34:2596-602.
Lanzkowsky P. Disorders of white blood cells. In: Manual of Pediatric Hematology and Oncology. 4th ed. London: Elsevier Academic Press, 2005:209-49.
Akut Boxer LA. Eosinophils. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Saunders Elsevier, 2007:902-3.
Bass DA, Gonwa TA, Szejda P, Cousart MS, DeChatelet LR, McCall CE. Eosinopenia of acute infection: Production of eosinopenia by chemotactic factors of acute inflammation. J Clin Invest 1980;65:1265-71.
Gil H, Magy N, Mauny F, Dupond JL. Value of eosinopenia in inflammatory disorders: An “old” marker revisited. Rev Med Interne 2003; 24:431-5 (in French).
Lo´pez de Toro M, Consuegra I, Sa´nchez Casado M, Rodrı´guez Villar S, Raigal Can˜o A, et al. Evaluation of eosinopenia as an infection marker in critical care patients. Med Intensiva 2010;34: 246-53.
Shaaban H, Daniel S, Sison R, Slim J, Perez G. Eosinopenia: Is it a good marker of sepsis in comparison to procalcitonin and C-reactive protein levels for patients admitted to a critical care unit in an urban hospital? J Cri tCare 2010;25:570–5.
Abidi K, Khoudri I, Belayachi J, Madani N, Zekraoui A, Zeggwagh AA, et al. Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care 2008;12:59.
Smithson A, Perello´ R, Nicolas JM. Is eosinopenia a reliable marker of sepsis? Crit Care 2009;13:409.
Arkader R, Troster EJ, Lopes MR, Junior RR, CarcilloJA, Leone C, et al. Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome. Arch Dis Child 2006;91:117-20.
Hatherill M, Tibby SM, Sykes K, Turner C, Murdoch IA. Diagnostic markers of infection: Comparison of procalcitonin with C reactive protein and leucocyte count. Arch Dis Child 1999;81:417-21.

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How to cite

Kanberoğlu Gİ, Bağ Ö, Karaarslan U, Öztürk SEA, Ecevit Ç, Öztürk SEA. The Importance of the Presence of Eosinopenia in the Diagnosis of Bacterial Infection. Turk J Pediatr Dis [Internet]. 2015 Dec. 1 [cited 2025 May 24];9(4):239-42. Available from: https://turkjpediatrdis.org/article/view/302

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[ref1] Hoffman, Hematology Basic Principles and practice. 3rd ed, Churchill Livingstone 2000.

[ref2] Zappert J. Ueberdas Vorkommen der Eosinophilen Zellen in menschlichen Blute. Z Klin Med 1893;23:227-308.

[ref3] Simon CE. A manual of clinical diagnosis. London. Henry Klimpton 1922:53.

[ref4] Aygun G. Sepsis tanısı. İçinde: Guncel bilgiler ışığında sepsis. İ.U. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri Sempozyum Dizisi. No: 51. İstanbul: 2006:51-60.

[ref5] Rey C, Los Arcos M, Concha A, Medina A, Prieto S, Martinez P, Prieto B. Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill children. Intensive Care Med 2007;33:477-84.

[ref6] Devrim İ, Secmeer G. Prokalsitoninin çocukluk döneminde kullanımı. Hacettepe Tıp Dergisi 2006;37:217-22.

[ref7] Jensen JU, Heslet L, Jensen TH, Espersen K, Steffensen P, Tvede M. Procalcitonin increase in early identification of critically ill patients at high risk of mortality. Crit Care Med 2006;34:2596-602.

[ref8] Lanzkowsky P. Disorders of white blood cells. In: Manual of Pediatric Hematology and Oncology. 4th ed. London: Elsevier Academic Press, 2005:209-49.

[ref9] Akut Boxer LA. Eosinophils. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF eds. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Saunders Elsevier, 2007:902-3.

[ref10] Bass DA, Gonwa TA, Szejda P, Cousart MS, DeChatelet LR, McCall CE. Eosinopenia of acute infection: Production of eosinopenia by chemotactic factors of acute inflammation. J Clin Invest 1980;65:1265-71.

[ref11] Gil H, Magy N, Mauny F, Dupond JL. Value of eosinopenia in inflammatory disorders: An “old” marker revisited. Rev Med Interne 2003; 24:431-5 (in French).

[ref12] Lo´pez de Toro M, Consuegra I, Sa´nchez Casado M, Rodrı´guez Villar S, Raigal Can˜o A, et al. Evaluation of eosinopenia as an infection marker in critical care patients. Med Intensiva 2010;34: 246-53.

[ref13] Shaaban H, Daniel S, Sison R, Slim J, Perez G. Eosinopenia: Is it a good marker of sepsis in comparison to procalcitonin and C-reactive protein levels for patients admitted to a critical care unit in an urban hospital? J Cri tCare 2010;25:570–5.

[ref14] Abidi K, Khoudri I, Belayachi J, Madani N, Zekraoui A, Zeggwagh AA, et al. Eosinopenia is a reliable marker of sepsis on admission to medical intensive care units. Crit Care 2008;12:59.

[ref15] Smithson A, Perello´ R, Nicolas JM. Is eosinopenia a reliable marker of sepsis? Crit Care 2009;13:409.

[ref16] Arkader R, Troster EJ, Lopes MR, Junior RR, CarcilloJA, Leone C, et al. Procalcitonin does discriminate between sepsis and systemic inflammatory response syndrome. Arch Dis Child 2006;91:117-20.