Öz

Amaç: Agresif posterior prematüre retinopatisi olan prematüre bebeklerde intravitreal bevacizumab enjeksiyonunun sistemik, lokal etkilerini ve yan etkilerini değerlendirmek.

Gereç ve Yöntemler: Haziran 2020 ile Mart 2021 arasında tek merkezli gözlemsel kohort çalışmasına toplam 16 hasta dahil edildi. Toplam 32 göz için intravitreal 0.3 mg bevacizumab enjeksiyonu öncesi ve sonrası klinik, laboratuvar ve radyolojik bulgular kaydedildi.

Bulgular: Hastaların doğumdaki ortalama gestasyonel yaşı 25±0.38 hafta ve ortalama doğum ağırlığı 695±119.2 gr’dı. Hiçbir hastada postmenstrüel 34 haftalıkken intravitreal enjeksiyona sekonder lokal vitreus kanaması veya endoftalmit gibi komplikasyonlar gelişmedi, hiçbirinde tekrarlanan enjeksiyon gerekmedi. Enjeksiyondan sonra intraventriküler kanama oranında artış olmadı. Tedavi öncesi ve sonrası hastaların laboratuvar parametreleri, kan basıncı değerleri veya sistemik bulguları arasında istatistiksel olarak anlamlı bir fark yoktu.

Sonuç: Bu çalışmada intravitreal bevacizumab enjeksiyonu ile tedavi edilen hastalarda sistemik veya lokal yan etki görülmemekle birlikte hastalar sistemik hipertansiyon, intraventriküler kanama ve hipotansiyon açısından yakından izlenmelidir. Diğer tedavi seçeneklerine kıyasla daha sonraki nörogelişimsel sonuçları değerlendirmek için daha ayrıntılı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler: Bevacizumab, İntraventriküler kanama, Hipotansiyon, Hipertansiyon, Prematüre Retinopatisi

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Telif hakkı ve lisans

Nasıl atıf yapılır

1.
Elbayiyev S, Özdemir Ö, Ceran B, Akın MŞ, Canpolat FE, Oguz S. İntravitreal Bevacizumab Uygulanan Prematüre Retinopatisi Olan Bebeklerin Değerlendirilmesi. Turk J Pediatr Dis [Internet]. 2022 Sep. 20 [cited 2025 May 25];16(5):368-73. Available from: https://turkjpediatrdis.org/article/view/846