Topikal Steroide Sekonder İatrojenik Cushing Sendromu

A. Esin Kibar; Derya Soy; Zehra Aycan; Ergun Çetinkaya

Research Article

Turk J Pediatr Dis 2007; 1(1): 43-47.

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IATROGENIK CUSHING’S SYNDROME SECONDARY TO TOPICAL STEROID TREATMENT

Authors

A. Esin Kibar

Derya Soy

Zehra Aycan

Ergun Çetinkaya

Affiliations

Turk J Pediatr Dis 2007; 1(1): 43-47.

Published: June 1, 2007

Abstract

Topical corticosteroids, frequently used by physicians in the treatment of various skin diseases like diaper dermatitis, may rarely lead to Cushing's syndrome and suppress ACTH secretion functions of the adrenal gland. In this manuscript, two cases of 5 months old girls, whose adrenal functions were suppressed due to the 0.05% Clobetasol 17-propionate treatment usage, are presented. Subjects admitted with complaints of swollen face and hypertrichosis following the 2-5 months use of Clobetasol 17- propionate for diaper dermatitis. Physical examination revealed that the body weight and height were 5 kg (<3p) and 57 cm (<3p), respectively, in subject 1 and 6.2 kg (3-10 p) and 59 cm (3-10p), respectively, in subject 2. Cushingoid appearance and hypertrichosis of the cheeks and the back were observed in both subjects. Laboratory examination demonstrated plasma ACTH levels of

Keywords: Iatrogenic Cushing’s syndrome, topical steroid

References

Siklar Z, Bostanci I, Atli O, Dallar Y. An infantile Cushing syndrome due to misuse of topical steroid. Pediatr Dermatol. 2004;21:56-63.
Gaillarg RC. Neuroendocrine regulation. In: Bertrand J, Rappaport R, Sizonenkp PC (eds). Pediatric Endocrinology. 2 nd edition. USA: Williams & Wilkins, 1993; 19-45.
Keller-Wood ME, Dallman MF. Corticosteroid inhibition of ACTH secretion. Endoc Rev 1984; 5: 1-14.
Turpeinen M, Salo OP, Leisti S. Effect of percutaneous absorption of hydrocortisone on adrenocortical responsiveness in infants with severe skin disease. Br J Dermatol 1986;115:475-484.
Ermis B, Ors R, Tastekin A, Ozkan B. Cushing's syndrome secondary to topical corticosteroids abuse. Clin Endocrinol 2003; 58: 795-796.
Ohman EM, Rogers S, Meenan FO, McKenna TJ. Adrenal suppression following low-dose topical clobetasol propionate. J R Soc Med 1987; 80: 422-424.
Curtis JA, Cormode E,Laski B, Toole J, Howard N. Endocrine complications of topical and intralesional corticosteroid therapy. Arch Dis Child 1982;57:204-207.
Ozon A, Cetinkaya S, Alikasifoglu A, Gonc EN, Sen Y, Kandemir N. Innappropriate use of potent topical glucocorticoids in infants. J Pediatr Endocrinol Metab 2007; 20: 219-225.

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How to cite

Kibar AE, Soy D, Aycan Z, Çetinkaya E. IATROGENIK CUSHING’S SYNDROME SECONDARY TO TOPICAL STEROID TREATMENT. Turk J Pediatr Dis [Internet]. 2007 Jun. 1 [cited 2025 May 24];1(1):43-7. Available from: https://turkjpediatrdis.org/article/view/8

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[ref1] Siklar Z, Bostanci I, Atli O, Dallar Y. An infantile Cushing syndrome due to misuse of topical steroid. Pediatr Dermatol. 2004;21:56-63.

[ref2] Gaillarg RC. Neuroendocrine regulation. In: Bertrand J, Rappaport R, Sizonenkp PC (eds). Pediatric Endocrinology. 2 nd edition. USA: Williams & Wilkins, 1993; 19-45.

[ref3] Keller-Wood ME, Dallman MF. Corticosteroid inhibition of ACTH secretion. Endoc Rev 1984; 5: 1-14.

[ref4] Turpeinen M, Salo OP, Leisti S. Effect of percutaneous absorption of hydrocortisone on adrenocortical responsiveness in infants with severe skin disease. Br J Dermatol 1986;115:475-484.

[ref5] Ermis B, Ors R, Tastekin A, Ozkan B. Cushing's syndrome secondary to topical corticosteroids abuse. Clin Endocrinol 2003; 58: 795-796.

[ref6] Ohman EM, Rogers S, Meenan FO, McKenna TJ. Adrenal suppression following low-dose topical clobetasol propionate. J R Soc Med 1987; 80: 422-424.

[ref7] Curtis JA, Cormode E,Laski B, Toole J, Howard N. Endocrine complications of topical and intralesional corticosteroid therapy. Arch Dis Child 1982;57:204-207.