Abstract
Objective: Therapeutic plasma exchange (TPE) is an extracorporeal treatment that enables the removal of undesirable large molecular weight substances from the blood. We aimed to investigate the data and results of patients who underwent TPD in our intensive care unit for a 5-year period, with the latest American Apheresis Association(ASFA) category classification in 2019.
Material and Methods: The demographic data, clinical diagnostic laboratory data of the patients who were hospitalized in the Pediatric Intensive Care Unit between January 1, 2014 and January 1, 2019 were retrospectively analyzed from the patients’ files and apheresis unit records. TPE procedure was performed at the bedside of the patient by apheresis unit teams.
Results: A total of 40 patients were included in the study. 122 sessions of TPE were applied. Twenty-seven (67.5%) of the patients who underwent TPE were transferred to the service with a response to treatment. 13 (32.5%) patients died. The most common TPE indication was Liver Failure. The median time of administration was 105.5 minutes (25-234) and the median day of hospitalization was 14.5 (1-90). Central route was used in 39 (97.5%) patients and peripheral route was used in 1 patient. While complications developed in 11 (27.5%) patients during TPE, the most frequent complications were (45.4%) catheter occlusion and decreased blood flow.
Conclusion: The increasing of pediatric intensive care units in our country and the increase of equipment have increased the applicability of procedures such as TPE and hemodialysis. Our study suggests that TPE can be life-saving in the correct indication for supportive therapy.
Keywords: Apheresis, Pediatric İntensive Care, Therapeutic plasma exchange
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