Abstract

Objective: Iron deficiency anemia is still one of the most common nutrition related hypochrome and microcytic anemias worldwide. Thrombocytosis in peripheral blood is common with IDA and its causes are not well known. In this study, we investigated the characteristics, frequency and causes of thrombocytosis in children with IDA.

Material and Methods: Age, sex, blood count parameters, serum iron and iron binding capacity, ferritin levels, presence of concomitant infection were investigated and the presence and causes of thrombocytosis were seeked at outpatient clinics in children with IDA.

Results: The mean age of 267 patients with IDA (M/F: 109/158) was 7.0 ± 6.3 years. Mean Hb value of the patients was 8.9 ± 1.8 (4.6-11.9) g/dL, mean MCV 65.2 ± 8.1 (47.1-84.6) fL, mean platelet count 392.250 ± 146.805 (114.000-1.239.000) / mm3, mean TS 5.1 ± 2.6 (1.09- 12.57), the median value of ferritin was 3.4 (range 0.1-344) ng/mL. Deep anemia with hemoglobin below 7g/dL was detected in 50 patients (18.7%).Of the patients with iron deficiency anemia, 112 (41.9%) were infants younger than 2 years of age, and 97 (36.3%) were adolescents aged 12 years and older. Out of the anemic adolescents, 84 (86.5%) were female. Thrombocytosis was detected in 71 (26.6%) patients.

Mean platelet counts of patients with and without thrombocytosis were 578.197 ± 134.779/mm3 and 324.892 ± 75.686/mm3, respectively. Thrombocytosis was more common in male patients and in patients with infection. In patients with thrombocytosis the mean age, Hb, MCV and MPV were statistically lower, and WBC and ANC were higher than in anemic group without thrombocytosis (p<0.05). There was a moderate but significant negative correlation between platelet count and mean platelet volume (r= -0.330, p=<0.001).

Conclusion: IDA is still one of the most important public health problems in our country as it is in the world and it is frequently seen in infants and particularly in the adolescent girls. Our results are consistent with the literature, the incidence of thrombocytosis increases as iron deficiency deepens and when infection is present.

Keywords: Child, Iron deficiency anemia, Thrombocytosis

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How to cite

1.
Yazal Erdem A, Yazıcıoğlu B. Evaluation of Pediatric Patients with Iron Deficiency Anemia and Assessment of Causes of Thrombocytosis. Turk J Pediatr Dis [Internet]. 2020 Mar. 18 [cited 2025 Aug. 23];14(2):147-52. Available from: https://turkjpediatrdis.org/article/view/706