Abstract
A series of pneumonia cases of unknown etiology have been reported in Wuhan, China since December 2019. This life-threating respiratory disease, named COVID -19 is caused by infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and it has transmitted to other countries spread around the world. There are limited case series reporting the influence on pregnant women and newborn with COVID 19. The management for newborn and children with COVID-19 is based on adult experience. This article reviews the current knowledge of COVID-19 infection in newborns and pregnant women. Important details are summarized about breastfeeding, prevention, clinical characteristics, diagnosis and strategies of treatment of newborn and pregnant women in this review.
Keywords: COVID-2019, Pregnancy, Neonatal infection, SARSCoV-2
References
- Chu-Xia Deng . The global battle against SARS-CoV-2 and COVID-19. Int J Biol Sci 2020; 16(10):1676-1677
- Qing Cao, Yi-Ching Chen, Chyi-Liang Chen, Cheng-Hsun Chiu. SARS-CoV-2 infection in children:Transmission dynamics and clinical characteristics. J Formos Med Assoc. 2020 Mar;119(3):670-673
- Zeng LK, Tao XW, Yuan WH, Wang J, Liu X, Liu ZS. First case of neonate with COVID 19 in China. Zhonghua Er Ke Za Zhi. 2020 Apr 2;58(4):279-280
- Li H, Liu SM, Yu XH, Tang SL, Tang CK.Coronavirus disease 2019 (COVID-19): current status and future perspective. Int J Antimicrob Agents. 2020 Mar 28:105951
- Park SE. Epidemiology, virology, and clinical features of severe acute respiratory syndrom – coronavirus -2 (SARS-CoV-2; Coronavirus Disease-19). Clin Exp Pediatr. 2020 Apr 2
- Tanu Singhal . A Review of Coronavirus Disease-2019 (COVID-19). Indian J Pediatr. 2020 Apr;87(4):281-286.
- Lu Qi, Shi Yuan. Coronavirus disease (COVID‐19) and neonate: What neonatologist need to know. J Med Virol. 2020 Mar 1
- Dong L, Tian J, He S, Zhu C, Wang J, Liu C, Yang J. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. 2020 Mar 26.
- Chandrasekharan P, Vento M, Trevisanuto D, Partridge E, Underwood MA, Wiedeman J, et al. Neonatal Resuscitation and Postresuscitation Care of Infants Born to Mothers with Suspected or Confirmed SARS-CoV-2 Infection. Am J Perinatol. 2020 Apr 8
- van Doremalen N, Bushmaker T, Morris DH, Holbrook MG, Gamble A, Williamson BN, Tamin A, Harcourt JL, Thornburg NJ, Gerber SI, Lloyd-Smith JO, de Wit E, Munster VJ. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. 2020 Mar 17
- Laishuan Wang, Yuan Shi, Tiantian Xiao, Jianhua Fu , Xing Feng, Dezhi Mu,et al. Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition). Ann Transl Med 2020;8:47.
- Kamali Aghdam M, Jafari N, Eftekhari K. Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. Infect Dis (Lond). 2020 Apr 1:1-3.
- De Luca D. Managing neonates with respiratory failure due to SARS-CoV-2. Lancet Child Adolesc Health. 2020 Apr;4(4):e8
- Wang C, Zhou YH, Yang HX, Poon LC. Intrauterine vertical transmission of SARS-CoV-2: what we know so far. Ultrasound Obstet Gynecol. 2020 Apr 7.
- Davanzo R, Moro G, Sandri F, Agosti M, Moretti C, Mosca F. Breastfeeding and Coronavirus Disease-2019. Ad interim indications of the Italian Society of Neonatology endorsed by the Union of European Neonatal & Perinatal Societies.. Matern Child Nutr. 2020 Apr 3:e13010
- Choi SH, Kim HW, Kang JM, Kim DH, Cho EY. Epidemiology and Clinical Features of Coronavirus disease 2019 in Children. Clin Exp Pediatr. 2020 Apr 6
- Dashraath P, Jing Lin Jeslyn W, Mei Xian Karen L, Li Min L, Sarah L, Biswas A, Arjandas Choolani M, Mattar C, Lin SL.Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy. Am J Obstet Gynecol. 2020 Mar 23.
- Anderson PO. Breastfeeding and Respiratory Antivirals: Coronavirus and Influenza. Breastfeed Med. 2020 Mar;15(3):128.
- Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, Feng L. A case report of neonatal COVID-19 infection in China. Clin Infect Dis. 2020 Mar 12
- Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J, Zhou W. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. 2020 Mar 26.
- Huan Liang. Ganesh Achary. Novel corona virus disease (COVID-19) in pregnancy: What clinical recommendations to follow. Acta Obstet Gynecol Scand. 2020 Apr;99(4):439-442
- Mullins E, Evans D, Viner R, et al. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol. 2020 Mar 17.
- Royal College of Obstetricians & Gynecologists (2020). Coronavirus (COVID-19) Infection in Pregnancy. Information for healthcare professionals. Version 2: Published Thursday 26 March. https://www.rcog.org.uk/globalassets/documents/guidelines/2020-03-26-covid19-pregnancy-guidance.pdf.
- Motta M, Tincani A, Faden D, Zinzini E, Lojacono A, Marchesi A, et al. Follow up of infants exposed to hydroxychloroquine given to mothers during pregnancy and lactation.J Perinatol 2005;25:86-9
- Grein J, Ohmagari N, Shin D, Diaz G, Asperges E, Castagna A, et al. Compassionate Use of Remdesivir for Patients with Severe Covid-19. N Engl J Med. 2020 Apr 10.doi: 10.1056/NEJMoa2007016. [Epub ahead of print]
- Dörnemann J, Burzio C, Ronsse A, Sprecher A, De Clerck H, Van Herp M, et al. First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease.J Infect Dis 2017;215:171-4.
- Luo P, Liu Y, Qiu L, Liu X, Liu D, Li J.Tocilizumab treatment in COVID-19: A single center experience. J Med Virol 2020 Apr 6.doi: 10.1002/jmv.25801. [Epub ahead of print]
- Saito J, Yakuwa N, Kaneko K, Takai C, Goto M, Nakajima K, et al. Tocilizumab during pregnancy and lactation: drug levels in maternal serum, cord blood, breast milk and infant serum. Rheumatology (Oxford) 2019;58:1505-7.
- Hayden FG, Shindo N. Influenza Virus Polymerase Inhibitors in Clinical Development. Curr Opin InfectDis 2019;32:176-86.
Copyright and license
Copyright © 2020 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.