Abstract

Objective: The aim of this study was to evaluate the clinical, laboratory
and etiological differences between children having acute pancreatitis, acute
recurrent pancreatitis and chronic pancreatitis.

Method: Medical records of children who were diagnosed with
pancreatitis between January 2014 and December 2017 were evaluated
retrospectively.  The study was approved
by the Ethics Committee of Afyonkarahisar University of Health Sciences. Our cases were classified as acute
pancreatitis, acute recurrent pancreatitis and chronic pancretitis according to
INSPPIRE group definitions.

Results:
Etiology, demographic characteristics, laboratory and radiological findings
were compared between acute pancreatitis (group 1) and acute recurrent and
chronic pancreatitis (group 2) groups. 43 patients (78.2%) were enrolled in
acute pancreatitis group (group 1). In group 2; 8 cases had acute recurrent
pancreatitis and 4 cases had chronic pancreatitis [a total of 12 cases (21.8%)].  the etiologies of our cases were examined;  Group 1 had idiopathic (88.5%), stone (2.3%),
trauma (2.3%), infections (4.6%) and choledochal cyst (2.3%), respectively. In
group 2, they were found to be idiopathic (50%), congenital anomalies of the
pancreatic duct (8.3%), allergy (8.3%), autoimmunity (8.3%) and genetic causes
(25%). There was no statistical difference between the groups in terms of
laboratory values. In our study, the cause of pancreatitis could not be generally
identified in all groups.

Conclusions:
 In cases having acute pancreatitis,
infections were the second most common etiology; and common causes of acute
recurrent and chronic pancreatitis have been found as genetic causes.

Keywords: acute pancreatitis, acute recurrent pancreatitis, chronic pancreatitis, etiology

References

  1. 1. Werlin SL, Wilschanski M. Acute pancreatitis. In: Kliegman RM, ed. Nelsons Essentials of Pediatrics. 20th ed. Philadelphia, PA: Saunders/Elsevier; 2016:1913-14. 2. Morinville, V. D., Lowe, M. E., Ahuja, M., Barth, B., Bellin, M. D., Davis, H., et.al. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014;59(3):360-364. doi:10.1097/MPG.0000000000000417. 3. Morinville V.D, Husain S.Z, Bai H, Barth B, Alhosh R, Durie P.R, et al. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr. 2012;55(3):261-265. doi:10.1097/MPG.0b013e31824f15164. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-184. doi:10.1038/s41575-018-0087-55. Poddar U, Yachha SK, Borkar V, Srivastava A, Kumar S. A Report of 320 Cases of Childhood Pancreatitis. Pancreas. 2017;46(1):110-115. doi:10.1097/MPA.00000000000007336. Kandula L, Lowe ME. Etiology and Outcome of Acute Pancreatitis in Infants and Toddlers. J Pediatr. 2008;152(1):106-110.e1. doi:10.1016/J.JPEDS.2007.05.0507. Pant C, Deshpande A, Olyaee M, Anderson M P, Bitar A, Steele M.I, et al. Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009. Rakonczay Z, ed. PLoS One. 2014;9(5):e95552. doi:10.1371/journal.pone.00955528. Ünlüsoy Aksu A, Sarı S, Eğritaş Gürkan Ö, Dalgıç B. Türk çocuklarda pankreatit: tek merkez deneyimi. Cukurova Med J. 2019;44(3):1-1. doi:10.17826/cumj.5116059. Alabdulkareem A, Almahmoud T, Al-Tahan H, Javad S, Al Hatlani M. Etiology and clinical characteristics of pediatric acute pancreatitis in Saudi Arabia: a 20-year experience from a single tertiary center. Int J Pediatr Adolesc Med. 2018;5(1):13-17. doi:10.1016/j.ijpam.2018.01.00110. Bai HX, Lowe ME, Husain SZ. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr. 2011;52(3):262-270. doi:10.1097/MPG.0b013e3182061d7511. Taylor C.J, Chen K, Horvath K, Hughes D, Lowe M.E, Mehta D, et al. ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children. 2015. doi:10.1097/MPG.00000000000008312. Abu-El-Haija M, Kumar S, Quiros J.A, Balakrishnan K, Barth B, Bitton S, et al. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2018; 66(1):159-176. doi:10.1097/MPG.0000000000001715
  2. 2. Morinville, V. D., Lowe, M. E., Ahuja, M., Barth, B., Bellin, M. D., Davis, H., et.al. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr. 2014;59(3):360-364. doi:10.1097/MPG.0000000000000417.
  3. 3. Morinville V.D, Husain S.Z, Bai H, Barth B, Alhosh R, Durie P.R, et al. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr. 2012;55(3):261-265. doi:10.1097/MPG.0b013e31824f1516
  4. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol. 2019;16(3):175-184. doi:10.1038/s41575-018-0087-5
  5. Poddar U, Yachha SK, Borkar V, Srivastava A, Kumar S. A Report of 320 Cases of Childhood Pancreatitis. Pancreas. 2017;46(1):110-115. doi:10.1097/MPA.0000000000000733
  6. Kandula L, Lowe ME. Etiology and Outcome of Acute Pancreatitis in Infants and Toddlers. J Pediatr. 2008;152(1):106-110.e1. doi:10.1016/J.JPEDS.2007.05
  7. Pant C, Deshpande A, Olyaee M, Anderson M P, Bitar A, Steele M.I, et al. Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009. Rakonczay Z, ed. PLoS One. 2014;9(5):e95552. doi:10.1371/journal.pone.0095552
  8. Ünlüsoy Aksu A, Sarı S, Eğritaş Gürkan Ö, Dalgıç B. Türk çocuklarda pankreatit: tek merkez deneyimi. Cukurova Med J. 2019;44(3):1-1. doi:10.17826/cumj.511605
  9. Alabdulkareem A, Almahmoud T, Al-Tahan H, Javad S, Al Hatlani M. Etiology and clinical characteristics of pediatric acute pancreatitis in Saudi Arabia: a 20-year experience from a single tertiary center. Int J Pediatr Adolesc Med. 2018;5(1):13-17. doi:10.1016/j.ijpam.2018.01.001
  10. Bai HX, Lowe ME, Husain SZ. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr. 2011;52(3):262-270. doi:10.1097/MPG.0b013e3182061d75
  11. Taylor C.J, Chen K, Horvath K, Hughes D, Lowe M.E, Mehta D, et al. ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children. 2015. doi:10.1097/MPG.000000000000083
  12. . Abu-El-Haija M, Kumar S, Quiros J.A, Balakrishnan K, Barth B, Bitton S, et al. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr. 2018; 66(1):159-176. doi:10.1097/MPG.0000000000001715

How to cite

1.
Bükülmez A, Balıkoğlu P, Oflu AT, Özer Gökaslan Ç. PANCREATITIS IN CHILDREN: A SINGLE CENTER EXPERIENCE. Turk J Pediatr Dis [Internet]. 2020 Nov. 30 [cited 2025 May 24];14(6):522-7. Available from: https://turkjpediatrdis.org/article/view/651