Abstract

Objective: The aim of this study was to evaluate the clinical, laboratory and etiological differences between children having acute pancreatitis, acute recurrent pancreatitis and chronic pancreatitis.

Material and Methods: Medical records of children who were diagnosed with pancreatitis between January 2014 and December 2017 were evaluated retrospectively. The study was approved by the Ethics Committee of Afyonkarahisar University of Health Sciences. Our cases were classified as acute pancreatitis, acute recurrent pancreatitis and chronic pancretitis according to INSPPIRE group definitions.

Results: Etiology, demographic characteristics, laboratory and radiological findings were compared between acute pancreatitis (group 1) and acute recurrent and chronic pancreatitis (group 2) groups. 43 patients (78.2%) were enrolled in acute pancreatitis group (group 1). In group 2; 8 cases had acute recurrent pancreatitis and 4 cases had chronic pancreatitis [a total of 12 cases (21.8%)]. When the etiologies of our cases were examined; Group 1 had idiopathic (88.5%), stone (2.3%), trauma (2.3%), infections (4.6%) and choledochal cyst (2.3%), respectively. In group 2, they were found to be idiopathic (50%), congenital anomalies of the pancreatic duct (8.3%), allergy (8.3%), autoimmunity (8.3%) and genetic causes (25%). There was no statistical difference between the groups in terms of laboratory values. In our study, the cause of pancreatitis could not be generally identified in all groups.

Conclusion: In cases having acute pancreatitis, infections were the second most common etiology; and common causes of acute recurrent and chronic pancreatitis have been found as genetic causes.

Keywords: acute pancreatitis, acute recurrent pancreatitis, chronic pancreatitis, etiology

References

  1. Werlin SL, Wilschanski M. Acute pancreatitis. In: Kliegman RM, ed. Nelsons Essentials of Pediatrics. 20th ed. Philadelphia, PA: Saunders/Elsevier 2016:1913-4.
  2. Morinville VD, Lowe ME, Ahuja M, Barth B, Bellin MD, Davis H, et al. Design and implementation of INSPPIRE. J Pediatr Gastroenterol Nutr 2014;59:360-4.
  3. Morinville V.D, Husain S.Z, Bai H, Barth B, Alhosh R, Durie P.R, et al. Definitions of pediatric pancreatitis and survey of present clinical practices. J Pediatr Gastroenterol Nutr 2012;55:261-5.
  4. Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat Rev Gastroenterol Hepatol 2019;16:175-84.
  5. Poddar U, Yachha SK, Borkar V, Srivastava A, Kumar S. A Report of 320 Cases of Childhood Pancreatitis. Pancreas 2017;46:110-5.
  6. Kandula L, Lowe ME. Etiology and Outcome of Acute Pancreatitis in Infants and Toddlers. J Pediatr 2008;152:106-10.
  7. Pant C, Deshpande A, Olyaee M, Anderson M P, Bitar A, Steele MI, et al. Epidemiology of Acute Pancreatitis in Hospitalized Children in the United States from 2000–2009. Rakonczay Z, ed. PLoS One 2014;9:e95552.
  8. Grover AS, Freeman AJ, Abu-El-Haija M, Eisses JF, Gardner TB, Liu QY, et al. Updates in pediatric Pancreatology: proceedings of the North Amercian Society for Pediatric Gastroentrology, Heaptology, and nutrition frontiers in pediatric Pancreatology Symposium. J Pediatr Gastroenterol Nutr 2019; 68: e27-33
  9. Abu-El-Haija M, Kumar S, Szabo F, Werlin S, Conwell D, Banks P, et al. NASPGHAN Pancreas Committee. Classification of acute pancreatitis in the pediatric population: Clinical report from the NASPGHAN Pancreas Committee. J Pediatr Gastroenterol Nutr 2017;64: 984-90.
  10. Ünlüsoy Aksu A, Sarı S, Eğritaş Gürkan Ö, Dalgıç B. Türk çocuklarda pankreatit: tek merkez deneyimi. Cukurova Med J 2019;44:1-1.
  11. Alabdulkareem A, Almahmoud T, Al-Tahan H, Javad S, Al Hatlani M. Etiology and clinical characteristics of pediatric acute pancreatitis in Saudi Arabia: a 20-year experience from a single tertiary center. Int J Pediatr Adolesc Med 2018;5:13-7.
  12. Bai HX, Lowe ME, Husain SZ. What have we learned about acute pancreatitis in children? J Pediatr Gastroenterol Nutr 2011;52:262-70.
  13. Taylor CJ,Chen K,Horvath K,Hughes D,Lowe ME,Mehta D, et al. ESPGHAN and NASPGHAN Report on the Assessment of Exocrine Pancreatic Function and Pancreatitis in Children. J Pediatr Gastroenterol Nutr 2015;61:144-53.
  14. Abu-El-Haija M, Kumar S, Quiros J.A, Balakrishnan K, Barth B, Bitton S, et al. Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee. J Pediatr Gastroenterol Nutr 2018; 66:159-76.

How to cite

1.
Bükülmez A, Balıkoğlu P, Oflu AT, Özer Gökaslan Ç. PANCREATITIS IN CHILDREN: A SINGLE CENTER EXPERIENCE. Turk J Pediatr Dis [Internet]. 2020 Nov. 30 [cited 2025 Aug. 23];14(6):522-7. Available from: https://turkjpediatrdis.org/article/view/651