Abstract

Corticosteroids are commonly used drugs in the treatment of glomerular diseases and renal posttransplantation management. However, long-term use of systemic corticosteroids have substantial

side effects. The association of diabetic ketoacidosis with the use of systemic corticosteroids is

infrequently reported. We report a complication of diabetic ketoacidosis, associated with the use

of high dose corticosteroid for the treatment of focal segmental glomerulosclerosis; which

improved afterthe cessation of steroid therapy.

Keywords: Corticosteroid, focal segmental glomerulosclerosis, diabetic ketoacidosis.

References

  1. 1. YoshiW. EM, Buczkowski AK. Sim SM, Elliott TG, Scudaınore CH,
  2. Lcvin A, Tıldesley HD, Landsberg DN. Post-transplant diabetic
  3. ketoacidosis-ıı. possible coruıequcnce of immunosuppression with
  4. calcineurininhibitingagents. Tn.nsp1Iııt2000; 13: 69-72.
  5. 2. Kcshııvarz R, Mousavi M, Hassan C. Diabetic ketoacidosis in a child
  6. on FK506 immunosuppression arter a liver transplıınt. Pediatr Emerg
  7. Can: 2002; 18: 22-24.
  8. 3. Erııoy A, Ersoy C, Tekce H, YAVa.Scııoglu 1, Dilek K. Dia.betic ketoacidosis following devclopment of de nova diabetes in tenal transplant recipient associated with tııcrolimus. Transplıınt Proc 2004;36:
  9. 1407-1410.
  10. 4. Toyonaga T, Kondo T,Miyamura N, Selrigami T, Sonoda K, Kodama
  11. S, Shinıkami A. Shİ1'otani T, Anki E. Sudden onset of diabetes with
  12. ketoacidosis in a patlent treated with FK506/tacrolimus. Diabetes
  13. fu:s Clin Ptact2002; 56:13-18.
  14. 5. www.mdcoruıult.com (Cyclosporine, tacrolimus adverse reactions.
  15. MDConsult,Drugs).
  16. 6. O~ Kaya.alp. Tıbbi Farmakoloji Rasyonel Tedavi Yönünden.
  17. Ankara: Hacettepe-Taş Kitapçılık, 11. Baskı, 2005: 1000-1100.
  18. 7. Bernatd Schimmeı BP, Parke.r KL. Adenocoıticottopic
  19. hormone.In:Phannacologic basis of therapeutic. Hardınan JG,
  20. limited LE, 9tb. ed NewYork,Mc GmwHill İne, 1996; 1459-1486.
  21. 8. David-Neto E, Lemos FC, Fa.del LM, Agena F, Sata MY, Coccuza. C,
  22. Percira LM, de Castto MC, Lando VS, Nahas WC, Ianhcz LE. The
  23. dynamics of glucose metabolism under calcineurin inhibitors in the
  24. first year aftcr renal transplantatlon in nonobcsc patients. Transplııntatlon 2007; 84: 50-55.
  25. 9. Dundar B, Eren E, Oktern F, Dundar N, Tunc B, Canatan n Hyperosmolar non-ketotlc sytıdrome in a child associated with 1-ıı.sparaginase and prednisolone. Pediatt lnt 2007; 49: 256-257.
  26. 10. Yang JY, Cui XL, He XJ Non-ketotlc hyperosmolar coma complicatlng steroid trea.tment in dıildhood nephrosis. Pediatr Nephrol
  27. 1995;9:621-622.
  28. 11. Yoshioka K, Sa.ta T, Okada N, Ishii T, Imanishi M, Tanaka S, Kim T,
  29. Sugimoto T, Fujii S. Post-transplant diabetes with anti-glut:atnic acid
  30. decarboxykse antibody during tacrolimus therapy. Dia.bet.es Res Oin
  31. Ptact1998;42: 85-89.
  32. 12. Agarwall DK, Jeloka T, Sharma AP, Sharma RK. Steroid induccd diabetes mellitus prescntingas diabctic ketoacidosis. Indian J.Ncphrol
  33. 2002; 12: 122-123.
  34. 13. Iw.unoto T, Kagawa Y, Naito Y, Kuzuhııra S, Kojima M. Steroid
  35. induced diabetes mellituıı anıl re.la.ted risk fiı.ctors in patients with
  36. neurologic discases. Phatmacothctapy 2004; 24: 508-514.
  37. 14. Banac S, PcrsiC M, Cvijovic K. Steroid diabetes in childrcn with Crohn
  38. disease. ActaMed Croatica2002; 56: 35-38.
  39. 15. SpearML,Rceves G, Pearlman SA. Diabetic lretoacidosis after steroid
  40. administtation for bronchopulmonuydysplasia J Peı:inatol 1993; 13:
  41. 232-234.

Copyright and license

Copyright © 2008 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

1.
Yeşilkaya E, Ünlüsoy A, Fidan K, Aksu T, Buyan N, Cinaz P. DIABETIC KETOSIS DUE TO STEROID USE IN A CASE OF FOCAL SEGMENTALGLOMERULOSCLEROSIS. Turk J Pediatr Dis [Internet]. 2008 Apr. 1 [cited 2025 Aug. 23];2(3):37-40. Available from: https://turkjpediatrdis.org/article/view/43