Abstract

Vitamin B12 defi ciency with non-specifi c signs is uncommon in childhood. It often develops as a result of inadequate intake. Mothers with low socioeconomic status may develop vitamin B12 defi ciency. It should be kept in mind that this defi ciency has higher incidence rates in infants at birth and during feeding with only breast milk. Lack of vitamin B12 in breast milk may cause symptoms in the fi rst 2 years of age. Treatment of vitamin B12 defi ciency is important as it ensures a good clinical response and prevention of permanent neurological damage. We present a case diagnosed with vitamin B12 defi ciency

Keywords: Vitamin B 12 Defi ciency, Pancytopenia, Child

References

  1. Taskesen M, Yaramıs A, Katar S, Pirinccioglu AG, Soker M. Neurological presentations of nutritional vitamin B12 defi ciency in 42 breastfed infants in Southeast Turkey. Turk J Med Sci 2011;41:1091-6.
  2. Onal H, Adal E, Oner T, Onal Z, Aydın A. Gelişmekte olan ülkelerde önemli bir sorun: Annede ve yenidoğanda B12 vitamini eksikliği. Türk Ped Arş 2010;45:242-5.
  3. Lerner NB. 448.2 Vitamin B12 (Cobalamin) Defi ciency. In Kliegman R, Stanton B, et al. (eds). Nelson Textbook of Pediatrics. 19th ed. Philadelphia:Elsevier, 2011: 1655.
  4. Bay A, Oner AF, Nalbantoglu O, Demirtas M, Acıkgöz M. Megaloblastik anemili 45 olgunun klinik ve hematolojik yönden değerlendirilmesi. Van Tıp Dergisi 2006;13:46-8.
  5. Incecik F, Herguner MO, Altunbasak S, Leblebisatan G. Neurologic fi ndings of nutritional vitamin B12 defi ciency in children. Turk J Pediatr 2010; 52:17-21.
  6. Honzik T, Adamovicova M, Smolka V, Magner M, Hruba E, Zeman J. Clinical presentation and metabolic consequences in 40 breastfed infant with nutritional vitamin B12 defi ciency- What have we learned? Eur J Paediatr Neurol 2010;14:488-95.
  7. Oner T. Sağlıklı yenidoğanlarda ve annelerinde vitamin B12 eksikliğinin sıklığı. (Uzmanlık Tezi). İstanbul: T.C. Sağlık Bakanlığı Bakırköy Kadın Doğum ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, 2008.
  8. Koc A, Kocyigit A, Soran M, Demir N, Sevinc E, Erel O, et al. High frequency of maternal vitamin B12 defi ciency as an important cause of infantile vitamin B12 defi ciency in Sanliurfa province of Turkey. Eur J Nut 2006;45: 291-7.
  9. Halicioglu O, Sutcuoglu S, Koc F, Ozturk C, Albudak E, Colak A, et al. Vitamin B12 an folate statuses are associated with diet in pregnant women, but not with anthropometric measurement in term newborns. J Matern Fetal Neonatal Med 2012; 25:1618-21.
  10. Baytan B, Ozdemir O, Erdemir G, Gunes AM. Çocukluk çağında vitamin B12 eksikliği klinik bulgular ve tedavi. Uludağ Üniversitesi Tıp Fakültesi Dergisi 2007;33: 61-4.

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How to cite

1.
Akça H, Polat E, Malbora B, Tuygun N, Karacan CD. A Rare Cause of Pancytopenia: Vitamin B12 Deficiency. Turk J Pediatr Dis [Internet]. 2016 Apr. 1 [cited 2025 May 24];10(1):67-9. Available from: https://turkjpediatrdis.org/article/view/416