Radioiodine therapy (RIT) is a safe and effective treatment option for management of childhood-onset Graves' disease. The aim of this study was to evaluate the efficacy of RIT in 7 childhood-onset Graves' patients who had relapsed following the initial medical therapy. The patients consisted of 6 females and 1 male whose ages ranged from 11 to 14 years. All patients received propylthiouracil (3-6 mg/kg/day) as the initial antithyroid drug therapy. During 2-6 years follow-up, 6 patients did not show remission and the remaining one patient developed toxic hepatitis due to the antithyroid drugs. RIT (10-15 mCi) were given following antithyroid drug therapy. Remission was achieved in all patients within 3 months. No complication related to RIT was observed during 1 year follow-up. Our data demonstrated that RIT is an effective and safe therapy for childhood-onset Graves' patients who has relapsed disease after initial medical therapy

Keywords: Graves' disease, Radioiodine therapy