Abstract
Visceral Leishmaniasis (VL) is a life-threatening systemic infectious disease affecting the reticuloendothelial system. The disease is caused by a protozoan parasite of the genus Leishmaniasis and is endemic in many parts of the world. Visceral Leishmaniasis has been reported to be endemic in the Aegean, Mediterranean and Southeast Anatolia regions of Turkey and sporadic in other regions. Herein we present an 8-year-old male living in İzmit who presented at the Kocaeli Derince Training and Research Hospital with complaints of fever, fatigue and weight loss, was diagnosed with VL and was successfully treated with liposomal amphotericin-B. It must be kept in mind that VL can be seen in non-endemic areas due to changing environmental conditions, poor living standards and migration and should be considered in the differential diagnosis of patients presenting with fever, weight loss, massive splenomegaly and pancytopenia
Keywords: Child, Splenomegaly, Visceral leishmaniasis
References
- McGwire BS, Satoskar AR. Leishmaniasis: Clinical syndromes and treatment. QJM 2014;107:7-14.
- Minodier P, Garnier JM. Childhood visceral leishmaniasis in Provence. Arch Pediatr 2000;7:572-7.
- World Health Organisation. Control of the Leishmaniasis: Report of a meeting of the WHO Expert Committee on the Control of the Leishmaniasis, 22-26 March 2010. Geneva: WHO Technical Report Series no:949.
- Stockdale L, Newton R. A review of preventative methods against human leishmaniasis infection. PLoS Negl Trop Dis 2013;7:e2278.
- Günay Ü, Baytan B, Güneş AM. Çocukluk çağında Kala-Azar. Güncel Pediatri 2005;3:86-9.
- Ok UZ, Balcıoglu IC, Taylan Özkan A, Özensoy S, Özbel Y. Leishmaniasis in Turkey. Acta Trop 2002; 84:43-8.
- Kurşun E, Turunç T, Demiroğlu YZ, Solmaz S, Arslan H. On dört erişkin viseral leyişmanyoz olgusunun değerlendirilmesi. Mikrobiyol Bul 2013;47: 500-6.
- Kocabaş E, Antmen B, Alhan E, Yıldıztaş D, Aksaray N. Çocukluk çağında Kala Azar. ÇÜ Tıp Fakültesi Dergisi 1998;23:95-101.
- Yılmaz EA, Tanır G, Tuygun N, Taylan Özkan A. Visceral Leishmani- asis in 13 pediatric patients in Turkey: Treatment experience. Türki- ye Parazitoloji Dergisi 2009;33:259-62.
- Chappuis F, Sundar S, Hauli A, Ghalib H, Rijal S, Peeling RW, et al. Visceral Leishmaniasis: What are the needs for diagnosis, treatment and control? Nat Rev Microbiol 2007;5:873-82.
- van Griensven J, Diro E. Visceral Leishmaniasis. Infect Dis Clin North Am 2012;26:309-22.
- Güneş AM, Baytan B, Günay Ü, Çalışkan-Aynacı D. Kala azar ve lipozomal amfoterisin B ile tedavi. Çocuk Sağlığı ve Hastalıkları Dergisi 2004;47:103-6.
- Hicsönmez G, Ozsoylu S. Kala-azar in childhood: A survey of clinical and laboratory findings and prognosis in 44 childhood cases. Clin Pediatr (Phila) 1972;11:465-7.
- Totan M, Dağdemir A, Muslu A, Albayrak D. Visceral childhood Leishmaniasis in Turkey. Acta Paediatr 2001;91:62-4.
- Balasegaram M, Ritmeijer K, Lima MA, Burza S, Ortiz Genovese G, Milani B, et al. Liposomal amphotericin B as a treatment for human leishmaniasis. Expert Opin Emerg Drugs 2012;17:493-510.