Propranolol, one of the beta-adrenergic blocking agents, has an important role in the practice of general medicine and pregnancy induced hypertension. However, its use in pregnant women with pregnancy induced hypertension is contradictary, owing to a number of detrimental side effects that have been reported in the fetus and neonate. In this report, we reported two neonates with refractory hypoglycemia whose mothers have been treated with propranolol during gestation. Both newborns were admitted to our hospital due to cyanosis and determined hypoglycemia and apnea. They were treated with high glucose infusion (22 mg/kg/minute) and one of them required methyl- prednisolone therapy (2 mg/kg/day). We suggest that the women during pregnancy and lactation should be carefully treated, and the mode of therapy should be carefully determined due to possible fetal and neonatal side effects. The neonates born to mothers treated with betaadrenergic blocking agents (i.e. propranolol) during gestation should be closely monitored for hypoglisemia after delivery. Early treatment of possible side effects are important for beter longterm outcome. The history of maternal propranolol use should be carefully questioned in the neonates with refractory hypoglycemia

Keywords: Apnea, newborn, propranolol, persistent hypoglycemia