Abstract

Brucellosis is a zoonotic infectious disease that still has high morbidity in Turkey. In cases with brucellosis, pancytopenia is a rare complication, while anemia and thrombocytopenia can be commonly seen. An eight-year-old male patient presented at our pediatric outpatient clinic with fever, fatigue, chill, shivering and loss of weight. On physical examination and laboratory investigations, hepatosplenomegaly, fever, pancytopenia and 1/160 titer positive Brucella tube agglutination test were found. The patient clinically improved at the end of the second week and pancytopenia completely resolved at the end of the sixth week of combined treatment with rifampicin and doxycycline. We presented a patient who developed pancytopenia due to brucellosis in this case report due to the rarity of this complication

Keywords: Brucellosis, Pancytopenia

References

  1. Young EJ. Brucella species. In: Mandell GL, Bennet JE, Dolin R, eds. Principles and Practice of Infectious Disease. 5th ed. Philadelphia: Churchill-Livingstone, 2000:2389-93.
  2. American Academy of Pediatrics. Summaries of Infectious Diseases. In: Peter G, Red Book:1997 Report of the Committee on Infectious Diseases. 24th ed. Elk Grove Village, IL: American Academy of Pediatrics; 1997:157-9.
  3. Navarro-Martinez A, Solera J, Corredoira J, Beato JL, Martínez- Alfaro E, Atiénzar M, et al. Epididymoorchitis due to Brucella melitensis: A retrospective study of 59 patients. Clin Infect Dis 2001;33:2017-22.
  4. Kadanalı A ,Soypaçacı Z, Parlak M. Bruselloza Bağlı Bir Pansitopeni Olgusu. İnfeksiyon Dergisi (Turkish Journal of Infection) 2003;17: 93-4.
  5. Al-Eissa YA, Assuhaimi SA, Al-Fawaz IM, Higgy KE, Al-Nasser MN, Al-Mobaireek KF. Pancytopenia inchildren with brucellosis: Clinical manifestations and bone marrow findings. Acta Haematol 1993;89:132-6.
  6. Aysha MH, Shayib MA. Pancytopenia and other haematological findings in brucellosis. Scand J Haematol 1986;36:335-8.
  7. Karakukcu M, Patiroglu T, Ozdemir MA, Gunes T, Gumus H, Karakukcu C. Pancytopenia, a rare hematologic manifestation of brucellosis in children. J Pediatr Hematol Oncol 2004;26:803-6.
  8. Taşbakan MI, Yamazhan T, Gökengin D, Arda B, Sertpolat M, Ulusoy S, et al. Brucellosis: A retrospective evaluation. Trop Doct 2003;33:151-3.
  9. Citak EC, Citak FE, Tanyeri B, Arman D. Hematologic manifestations of Brucellosis in children: 5 Years Experience of an Anatolian Center. J Pediatr Hematol Oncol 2010;32:137-40.
  10. Zribi M, Ammari L, Masmoudi A, Tiouiri H, Fendri C. Clinical manifestations, complications and treatment of brucellosis: 45-patient study. Pathol Biol (Paris) 2009;57:349-52.
  11. Sevinc A, Buyukberber N, Camci C, Buyukberber S, Karsligil T. Thrombocytopenia in brucellosis: Case report and literature review. J Natl Med Assoc 2005;97:290–3.

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How to cite

1.
Bektaş MS, Okur M, Aktar F, Temel H, Başaranoğlu M. Pancytopenia in a Child with Acute Brucellosis. Turk J Pediatr Dis [Internet]. 2013 Oct. 1 [cited 2025 May 24];7(3):145-6. Available from: https://turkjpediatrdis.org/article/view/226