Abstract

The overall frequency of thrombocytopenia in infants born to mothers with ITP is quite low, and about 1-5% of infants will have platelet count less than 20 000/ µL at birth, and about 1% will have significant bleeding complications. Three infants with severe thrombocytopenia born to mothers with ITP are described in this report. The infants were born from two pregnancies. Two of the infants were twins, and were born to a mother with ITP diagnosed at 22nd weeks of gestation. Their cord blood platelet counts were 6600/µL, and 31900/µL, respectively. The third infant was born to a mother with chronic ITP. The lowest platelet count was 20600/µL at postnatal day five. All infants received intravenous immunoglobulin therapy and one of them received platelet suspension infusion. Although neonatal thrombocytopenia associated with ITP is generally moderate or mild, it is important to note that some infants will have severe thrombocytopenia for several days following delivery

Keywords: Neonatal Thrombocytopenia, IVIG, ITP

References

  1. Sainio S, Järvenpää AL, Renlund M, Riikonen S, Teramo K, Kekomäki R. Thrombocytopenia in term infants: a population- based study. Obstet Gynecol 2000;95(3): 441-6.
  2. Kuhle S, Mitchel K, Massicotte P, Andrew M. Hemostatic Disorders of the Newborn. Avery’s Diseases of the Newborn. 8th ed. Phila- delphia: Elsevier Saunders, 2005;76:1145-79.
  3. Wong W, Glader B. Approach to the Newborn Who Has Thrombocy- topenia. Neo Reviews 2004;5(10):444-50.
  4. Gill KK, Kelton JG. Management of idiopathic thrombocytopenic purpura in pregnancy. Semin Hematol 2000;37(3):275-89.
  5. Christiaens GC, Nieuwenhuis HK, Bussel JB. Comparison of plate- let counts in first and second newborns of mathers with immune thrombocytopenic purpura. Obstet Gynecol 1997; 91(4 Pt 1):546- 52.
  6. Luchtman L, Schwartz AL, Wilson DB. The Blood and Hematopoi- etic System Disease of the Fetus and Infant. Fanaroff and Mar- tin’s Neonatal- Perinatal Medicine. 8th ed, Philadelphia: Mosby, 2006;44(2):1344-56.
  7. Song TB, Lee JY, Kim YH, Choi YY. Low neonatal risk of thrombo- cytopenia in pregnancy associated with immune thrombocytopenic purpura. Fetal Diagn Ther 1999; 14(4):216-9.
  8. Cines DB, Bussel JB, Liebman HA, Luning Prak ET. The ITP syn- drome: pathogenic and clinical diversity. Blood 2009;113(26):6511- 21.
  9. Provan D, Newland A. Idiopathic thrombocytopenic purpura in adults. J Pediatr Hematol Oncol 2003; 25(Suppl 1):34-8.
  10. Stavrou E, McCrae KR. Immune thrombocytopenia in pregnancy. Hematol Oncol Clin North Am 2009;23(6):1299-316.
  11. Cines DB, Blanchette VS. Immune thrombocytopenic purpura. N Engl J Med 2002;346(13):995-1008.
  12. Gill KK, Kelton JG. Management of idiopathic thrombocytopenic purpura in pregnancy. Semin Hematol 2000;37(3):275-89.
  13. Kelton JG. Idiopathic thrombocytopenic purpura complicating pregnancy. Blood Rev 2002;16(1):43-6.
  14. Kaplan C. Immune thrombocytopenia in the foetus and the new- born: diagnosis and therapy.Transfus Clin Biol 2001;8(3):311-4.
  15. Murray NA. Evaluation and treatment of thrombocytopenia in the neonatal intensive care unit. Acta Paediatr 2002; 91(438):74-81.
  16. Massey GV, McWilliams NB, Mueller DG, Napolitano A, Maurer HM. Intravenous immunoglobulin in treatment of neonatal isoim- mune thrombocytopenia. J Pediatr 1987;111(1):133-5.

Copyright and license

How to cite

1.
Kılıçdağ H, Gülcan H. NEONATAL AUTOIMMUNE THROMBOCYTOPENIA DUE TO MATERNAL IMMUNE THROMBOCYTOPENIC PURPURA: REPORT OF THREE CASES. Turk J Pediatr Dis [Internet]. 2012 Apr. 1 [cited 2025 May 25];6(4):249-52. Available from: https://turkjpediatrdis.org/article/view/206