Abstract

Background: Kawasaki disease (KD) is a febrile systemic vasculitis of childhood and its etiology remains unknown. The leading cause of KD is acquired heart disease in developed countries. The aim of this study is to describe clinical and epidemiological characteristics of children with Kawasaki disease in our hospital.Material and method: Between December 2004 and January 2009; the medical records of the patients treated for KD at Dr. Sami Ulus Children’s Training and Research Hospital were reviewed retrospectively fort this study.

Results: Thirty five patients were diagnosed as having Kawasaki disease in our center. Male to female ratio was 2.5. The median age at diagnosis was 4 years. Skin rash (88.6%) was the leading accompying finding to fever. Coronary artery anomaly was detected in 3 (8.6%) patients. Classical KD and incomplete KD was found in 51.4% and 48.6% of the patients, respectively. Although conjunctivitis, oropharyngeal and peripheral extremity findings were more common in the classical KD group, the difference was statistically significant for only peripheral extremity findings between classical and incomplete KD groups (p=0.041). Age, gender, duration of fever, time for IVIG treatment, and laboratory findings were not different between two groups (p>0.05).

Conclusion: Early diagnosis and appropriate treatment of KD is important in terms of avoiding the cardiovascular complications; the leading cause of mortality and morbidity

Keywords: Kawasaki disease, classical form, incomplete form

References

  1. Kawasaki T. Acute febrile mucocutenous syndrome with lymphoid involvement with spesific desquamation of the fingers and toes in children. Arerugi 1967;16(3):178-222.
  2. Luqmani RA, Robinson H. Introduction to, and classification of the systemic vasculitides. Best Pract Res Clin Rheumatol 2001;15(2):187-202.
  3. Gardner-Medwin JM, Dolezolova P, Cummins C, Southwood TR. Incidence of Henoch-Schöenlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet 2002;360(9341):1197-202.
  4. Cimaz R, Falcini F. An update on Kawasaki disease. Auotoimmun Rev 2003;2(5):258-63.
  5. Burns JC, Glode MP. Kawasaki syndrome. Lancet 2004;364(9433):533-44.
  6. Yoskowitch A, Tewfik TL, Duffy CM, Moroz B. Head and neck manifestations of Kawasaki disease. Int J Pediatr Otorhinolaryngol 2000;52(2):123-9.
  7. Newburger J, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, et.al. Diagnosis, treatment, and long term management of Kawasaki disease. A statement for health professionals from the committee on rheumatic fever, endocarditis, and Kawasaki disease, council on cardiovascular disease in the young. American Heart Association. Circulation 2004;110:2747-71.
  8. Shingadia D, Bose A, Booy R. Could herpesvirus be the cause of Kawasaki disease? Lancet Infect Dis 2002;2(5):310-3.
  9. Satou GM, Giamelli J, Gewitz MH. Kawasaki disease: diag- nosis, management, and long-term implications. Cardiol Rev 2007;15(4):163-9.
  10. Ozdemir H, Ciftçi E, Tapisiz A, Ince E, Tutar E, Atalay S, et al. Clinical and Epidemiological Characteristics of Children with Ka- wasaki Disease in Turkey. J Trop Pediatr 2010;56(4):260-2.
  11. Yavuz T, Nişli K, Öner N, Ömeroğlu RE, Dindar A, Aydoğan Ü, et al. Kawasaki hastalığı; 34 olgu sunumu. Türk Pediatri Arşivi 2006;41(4):197-200.
  12. Baer AZ, Rubin LG, Shapiro CA, Sood SK, Rajan S, Shapir Y, et al. Prevalence of coronary artery lesions on the initial echo- cardiogram in Kawasaki syndrome. Arch Pediatr Adolesc Med 2006;160(7):686-90.
  13. Tseng CF, Fu YC, Fu LS, Betau H, Chi CS. Clinical spec- trum of Kawasaki disease in infants. Zhonghua Yi Xue Za Zhi 2001;64(3):168-73.
  14. Joffe A, Kabani A, Jadavji T. Atypical and complicated Ka- wasaki disease in infants. Do we need criteria? West J Med 1995;162(4):322-7.
  15. Sonobe T, Kiyosawa N, Tsuchiya K, Aso S, Imada Y, Imai Y, et al. Prevalence of coronary artery abnormality in incomplete Kawasaki disease. Pediatr Int 2007;49(4):421-6.
  16. Perrin L, Letierce A, Guitton C, Tran TA, Lambert V, Koné-Paut I. Comparative study of complete versus incomplete Kawasaki dis- ease in 59 pediatric patients. Joint Bone Spine 2009;76(5):481-5.
  17. Lang B, Duffy CM. Controversies in the management of Kawasaki disease. Best Pract Res Clin Rheumatol 2002;16(3):427-42.
  18. Vijayan AP, Dinesh KB, Dıvıa Nath KR. Coronary artery dilatation in incomplete Kawasaki disease. Indian Pediatr 2009;46(7):607-9.
  19. Kurotobi S, Toshisaburo N, Kawakami N, Sano T. Coronary di- ameter in normal infants, children and patients with Kawasaki disease. Pediatr Int 2002:44(1);1-4.
  20. Royle J, Burgner D, Curtis N. The diagnosis and management of Kawasaki disease. J Paediatr Child Health. 2005;41(3):87-93.
  21. Pinna GS, Kafetzis DA, Tselkas OI, Skevaki CL. Kawasaki dis- ease: an overview. Curr Opin Infect Dis 2008;21(3):263-70.
  22. Du ZD, Di Z, Du JB, Lu S, Yi JM, Hou AC, et al. Comparison of efficacy among early, conventional and late intravenous gamma globulin treatment of Kawasaki disease. Zhonghua Yi Xue Za Zhi 2009;89(26):1841-3.
  23. Fukazawa R, Ogawa S. Long term prognosis of patients with Ka- wasaki disease: at risk for future atherosclerosis? J Nippon Med Sch 2009;76(3):124-33.
  24. Senzaki H. Long-term outcome of Kawasaki disease. Circulation 2008;118(25):2763-72.

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Copyright © 2011 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.

How to cite

1.
Örün UA, Doğan V, Karademir S, Öcal B, Tanır G. EVALUATION OF CHILDREN WITH KAWASAKI DISEASE. Turk J Pediatr Dis [Internet]. 2011 Jun. 1 [cited 2025 Aug. 23];5(3):149-55. Available from: https://turkjpediatrdis.org/article/view/149