Abstract

Çocuklarda ve gençlerde görülen Tip 2 diyabet, yüzyılımızda sıklığı giderek artan bir sağlık sorunu
haline gelmiştir. Hastalık ile ilgili veriler genellikle gelişmiş ülkelerden olmakla birlikte, gelişmekte
olan ülkelerden de az sayıda çalışma bildirilmiştir. Kronik bir hastalık olması ve uzun dönem takip
gerektirmesinin dışında, ülkelerin sağlık koruma sistemlerine önemli ekonomik yük getirmektedir.
Tip 2 diyabet ile ilişkili faktörler; aile hikayesi, genetik yatkınlık, insülin direnci, obesite ve metabolik
sendromdur. Bu yazının amacı; Tip 2 diyabet ve bununla ilişkili durumların, dünyada ve
Türkiye'de sıklığının giderek artmakta olduğunu vurgulamak, ayrıca ülkemizde ve dünyada
yapılan çalışmalar ışığında konuyu değerlendirmektir.

Keywords: Tip 2 diyabet, obezite, insülin direnci, metaboliksendrom

References

  1. Pihokcr C, Scott CR, Lcnsiııg SY, Cradock MM, SmithJ. Non-insulin depcndcnt diabetes mellitus in Africa.n-American youths of A:rlwısas. Clin Pcdiatt 1998; 37:97-102.
  2. Alberti KG, Ziı:runet PZ. Definition, diagnosis and clasification of diabetes mellitus and its complication. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consulu.tion. Diabct Med 1998; 15:539-553.
  3. Atabek ME, Pkgon O, Kurtoglu S. Prevalancc of mcu.bolic syndrome in abese 'Iırlcish children and adolescents. Diabetes Rcs Clin Pnc 2006; 72:315-321.
  4. Kclest:imur F, Cctio M, Pıı.saoglu H, Coksevim B, Ceıinkaya F, Unluhi.zarcı K, UnalS, Köl=AH. Theprevıılenoeandidentificationof risk factors fortypc2 diabetcs mellitus andimpaired glucosc t.olc-rancc in Kayseri, centralAnotolia, Turlrey.AcmDiabetol 1999; 36:85-91.
  5. Babaoğlu K, Hatun Ş, Atslıınoğlu Ü, Betekct A ~arlı:. Tip2 diyabetli erişkinlerin akrabası olan adolesanlarda glukoz intolcransının değcrlendirihnesi. VI. Ulusal Pcdiat:rik Endokrinoloji Koııgrcsi, 27-29 Eylül, 2001, Kayseri.
  6. '.fype 2 diabetes in children and adolescents. Ameı:ian Diabetcs Association Consensu Staıcment. Diabetes Care 2000; 23:381-389.
  7. Glaser NS. Non-insulin depcndent diabetes mellitus in chilclhood and adolcscence. PediattClinNotthAm 1997;44:307-337.
  8. Pınhas-Hamiel O, DolanLM, Daniels SR, Standifotd D, Khoury PR, Zcitler P. Incrcsascd incidcncc of non-insulin dcpcndcnt diabetcs mellitus amongadolcsccnts. J Pediatr 1996; 128:608-615.
  9. Kıtagawa T, Owada M, Umkami T, Tajima N. Epidomiology of type 1 (insulin dcpcndcnt) and type 2 (non-insulin dcpcndcnt) diabctcs mellitus in Japanese ehil dren. Diabetes Res Clin Pmc 1994; 24:7-13.
  10. Chuang LM, Sung FC, Lee CY, Lı n RR, Lı n CC, Chı ang CC. Incibetdcncc and prevıılcncc of childbood diabetcs in Taiwan-an c:xpcricnoe with nation-wide scrccning. Diabetes Rcs Clin Pnı.ct2002; 56:16.
  11. Wci JN, Sung FJ, Lin CC, Lin RS, Chiang CC, Chuang LM. National surveillancc for type 2 diabetes mellitus in Taiwancsc childtcn. )AMA 2003; 290:1345-1350.
  12. Anonymous. '.fype 2 diabetes in children and adolescents. American Diabetcs Association. Diabctes Carc2000;23:381-389.
  13. Wicgand S, Maikowski U, Blankenstein O, Bicbctmann H, Tamow P, Gruters A. '.fype 2 diabetes and impaitcd glucose tolerance in Europcan childtcn and adolcsccnts with obcsity - a problem that is na longcr restricted to minority groups. Eur J Endoctinol 2004; 151: 199- 206.
  14. Ta:saco B, Bueno G, Morcno LA, Gatııgorri JM, Bucno M. Insulin resistance and impaired glucose tolcrance in abese clıildten and adolcsccnts. J Physiol Biochcm 2003; 59:217-223.
  15. TeuscberT, Baillod P, Rosman JB, Teuscher A.Absence of diabetcs in a ıural Wcst African pop ula ti on with high catbohydratc/ cassava dict. Laru:ct 1987; 1:765-768.
  16. Ahrcn B, Corrigıı.n CB. Pa:valence of diabetes mellitus in notth-western Tanzania.Diabetologia 1984;26:333-336.
  17. Bai Pv, Krishnaswami CV, Chellamarippan M, Kumar GV, Subnmaniam JR, Srivatwa A, Subramanyam B, Rao MB. Prevalcncc of diabetcs in the young in south India. Indian Pediatt 1995; 32:1173- 1176.
  18. Kadiki OA, Rcddy MR, ManoukAA. Incidcncc of insulin dcpcndcnt diabetcs (IDDM) and non-insulin dcpendent diabetes (NIDDM) (0- 34 tears at onset) in B~ Libya. Diabetcs Rcs Clin Pnc 1996; 32:165-173.
  19. Llkitınaskul S, Kıat:tısa.tha~e P, Ouı.icbanwatana-Kı.ı.i K, Punna-kantaL, Angsusingha K, Tuclıında C. Incrcasing prevalence of type 2 dia.betes mellitus in Thai children and adolescents associated with increasiııg pıevalcncc of obcsity. J Pcdia.tt Endocrinol Metab 2003; 16:71-77.
  20. Silverman BL, Metzger BE, Cho NH, Loeb CA. Impaired glu.cose toletımce in adolescent offspring of dia.betic mothets. Relationship to fetal hyperinsulinism. Diabctes Care 1995; 18:611-617.
  21. Molyneaux L, Constantino M, Yue D. Sttoııg family historyptcdicts a younger age of onııet for subjects diagnosed with type 2 diabetes. DiabetcsObesMctab2004;6:187-194.
  22. Ka.rterAJ,Rowell SE, AckcrsonLM,Mitehell BO, FerraraA, Selgy JV; Ncwtnatı B. Excess ma=al ttansmission of typc 2 dia.betcs. Thc Northem C2lifomia Kaiııcr Permanente Diabetes Rcgistry. Diabetes Care 1999; 22:938-943.
  23. Lyssenko V, Anevski D, Sjogren M, Tuomı T, Groop L Genetic prcdiction of futuı:e typc 2 dia.bctes. Diabctes 2004; 53:30.
  24. Ll YF, Sun HX, Wıı GD, Du WN, Zu DI, Shen Y, Qiang BO, Yao Zİ, Wang H, Huang W, Chen Z, Xiocg .MM; Mccg Y, Fang FD. Protein kinase C/ zeta (PRKCZ) gene is associated with type 2 dia.betes in Han population of North Oıina and ana1ysis of its haplotypes. Woı:ld J Gasttoentero12003; 9:2078-2082.
  25. Sellets EA, Triggs-Raine B, Rockman-Gı:eenbetg C, Dean HJ. The prevalence of thc HNF-1alpha G319S mutation in Canadian aboriginal youth with type 2 dia.betes. Diabetes Care 2002; 25:2202- 2206.
  26. Deney AS, Fischcr B, Cecil JC, Boylan K, McGuingan FE, Raiston SH,MorrisAd,PalınerCN.AssociationoftheProt2AlaandC1431T variations of PPARG and their haplotypes with susceptibility to type 2dia.betes. Diabetologia 2004; 47:555-558.
  27. Goran MI, Gowcr BA. Longitudinal study on pubertal insulin rcsistance. Diabetes 2001; 50:2444-2450.
  28. Amiel SA, Sherwin RS, Simonson DC, Lauritııno AA, Tamborlane WV. Impaircd insulin actionin pubcrty. A contnburingfactorto poot glycemic conttol in adolescents with dia.betes. N Engl J Mcd 1986; 315:215-219.
  29. Matthcws DR, Hoskcr JP, Rudcnski AS, Naylor BA, Trcachcr DF, Tumcr RC. Homeostasis model assessmenı:: insulin rcsistance and beta-cell function &om fasting plasma glucose and insulin ooncenttationinman. Diabetologia 1985; 28:412-419.
  30. Keskin M, Kurtoglu S, Kendirci M, Atabek ME, Yazici C. Homcostasis model asscssment is morc rcliable than the fasting glucosc/insulin mtio and quantitativc insulin sensitivity check index for asscssing insulin resistancc among abese children and adolescents. Pedia.trics 2005; 115:500-503.
  31. AtabekME, Pirgon O, Kurtoglu S. Assessment of abnormal glu.cose homcostasis and insulin rcsistance in Turkish obesc children andadolcscents. Diabetcs ObcsMetab 2007; 9:304-310.
  32. Narayan KM, Hanson RL. Pettitt DJ, Bennett PH, Knowler WC. Atwo-stcp sttatcgy for identification of high-risk subjects fora clinical ttial of prcvcntion of NIDDM. Diabetcs Care 1996; 19:972-978.
  33. Satman 1, Yılmaz T, Sengül A, Salman S, Salman F, Uygur S, Bastar 1, Tütüncü Y, Sargt n M, Dinççag N, IWsidag K, Kalaça S, Ozcan S, King H, • Population based study of dia.betes and risk characıeristics in Turkey: result of the Torkish dia.betes epitemiologu study (I'URDEP). Diabetcs Care2002;25:1551-1556.
  34. Stern MP. Primary prcvention of type il dia.betes mellitus. Diabetes Care 1991;14:399-410.
  35. Tmyhum P, Beattıe JH. Physiological role of adipose tissue: white adiposc tissue as an cndocrinc and secrctory organ. Proc Nutt Soc 2001; 60:329-339.
  36. ChadranM, Phllips SA, Cıaraldi T,Henry RR. Adiponectin: more just another fat cellhormone ?. Diabetes Care 2003;26:2442-2450.
  37. Cruz M, Garcia-Macedo R, Garcia-Val.crio Y, Guticrrcz M, MedinaNavorro R, Duran C, Wacher N, Kumate]. Low adiponectin levcls predict type 2 dia.betcs in Maican children. Diabetcs Care 2004; 27:1451-1453.
  38. Atabek ME, Pilgon O, Kivtalı: AS. Evidence for association betwcen insulin resistanee and prcmaturc carotid atherosclcrosis in childhood obesity. Pedia.tt Rcs 2007; 61:345-349.
  39. Schınitz KH,Jacobs DRJr, HongCP, SteinbcrgcrJ,MoranA, Sınaiko AR. Association of physical activity with insulin sensitivity in childrcn.lntJObcsRelatMetabDisord2002;26:1310-1316.
  40. Schonfeld-Warden N, Warden CH. Pediattic obesity. An overview of ctiology and ttcatınent. Pediatt ClinNorthAm 1997; 44:339-361.
  41. Olivıu:ius ND, Andreasen AH. Wcight histDry and its impact on risk factors and dia.betic complications of newiy diagnosed dia.betic patients 40 ycars of agc and ovcr. 15"' IDF congrcss, Kobc, Japan. lnternationalDiabetes Federation, Bmssels, Belgium, 1994.
  42. Bennett PH, Knowlcr WC, Rushforth. NB. Thc role of obcsity in thc development of dia.betes in the Pima. Indians. in: Vague J, Vague PH, eds. Diabctes andobcsity. ExcrtaMedica, Oxford, 1979:117.
  43. Gowcr BA, Nagy TR, Goran MI. Vısceral fat, insulin sensitivity and lipids in prcpubcrtal childrcn.Diabctes 1999; 48:1515-1521.
  44. Rcwers M, Hamman RF. Risk fac1Xırs for non-insulin dependent dia.betes.In : Harris MI, ed. Diabetes in America. Washington, BC: National Institute of Health; 1995:179-220.
  45. Pradcepa R, Mohan V. Thc changiııg sccnario of thc dia.betcs epidcmic: implications for India. Indian J MedRcs 2002; 116:121-132.
  46. Aschncr P. Diabctes ttends in Latin America. Diabetes Metab Res Rev 2002; 18:27-31.
  47. Slyper AH. The pediatric obesity epidemic: causes and controversies.] Oin EndocrinolMetab 2004; 89:2540-2547.
  48. Ahmed ML, Ong KK. Morrell DJ, Cax L, Bmyer N, Perry L, Preece MA, Dunger DB. Longi.tudinal studyof leptin concentrations duı:ing puberty: scx differenccs and relıı.tionships to cl:wıge8 in body composition.] OinEndocrinolMetab 1999; 84:899-905.
  49. Byrnes SE, Baur LA, BergminghamM, BrockK, SteinbeckK Leptin and total cholcstcrol ate ptedi.cwrs of weight ga.in in pı:e-puperta.l chilclren. Int J Obes Relat Metab Disord 1999; 23: 146-150.
  50. Stefan N, Bunt JC, Salbc AD, Funaha Sbi T, Matsuzama Y, Tataranni PA. Plasıru. adiponectin concentrations in chilclren: relıı.tionsbips with obcsity and insulincınia. ] Oin Endocı:inol Metab 2002; 87:4652- 4656.
  51. Uckun-Kitapci A, Tezic T, Fı rııt S, Sipahi T, Barrier R, Edwıırds LJ, Calikoglu AS. Obesity and type 2 diıı.betes mellitus: a populationbased study of adolcsccnts.] Clin Endocı:inol Mc:tab 2004; 17:1633- 1640.
  52. MecklingKA, O SullivanC,Saaı:iD. Compariııonof alow-fatdiettoa low carbohydratc diet on weight loss, body composition and risk factors for diıı.betes and catdiovııscular disease in fı:ec...living, overweight men and women. J Clin Endocı:inol Metab 2004; 89:2717- 2723.
  53. Tan CE, Eırunanuel SC, Tan BY,Jacob E. Prewlence of diıı.betcıı and cthnic differcnccs in catdiovııscular risk factors. Thc 1992 Siııgapoı:e National Health Survey. D~bctcıı Carc 1999; 22:241-247.

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How to cite

1.
Alp H, Atabek ME. Çocuklarda Tip 2 Diyabet ve Risk Faktörleri. Turk J Pediatr Dis [Internet]. 2008 Apr. 1 [cited 2025 Aug. 23];2(3):58-64. Available from: https://turkjpediatrdis.org/article/view/1148