Abstract
Peliosis hepatis (PH) is an uncommon vascular disorder of the liver that may be caused by several etiologic agents and different pathogenetic mechanisms. Androgens which are widely used in the treatment of bone marrow failure syndromes can cause hepatic peliosis in rare cases. We describe a case of Fanconi aplastic anaemia in which PH developed after 4 years of treatment with androgens
Keywords: Peliosis hepatis, aplastic anaemia, androgen
References
- Velazquez I, Alter BP. Androgen and liver tumors: Fanconi’s anemia and non-Fanconi’s conditions. Am J Hematol 2004; 77:257-267
- Cavalcanti R, Pol S, Carton F, Campos H, Degott C, Driss F, Legendre C, Kreis H. Impact and evolution of peliosis hepatis in renal transplant recipients. Transplantation 1994; 58:315-316.
- Ahsan N, Holman MJ, Riley TR, Abendroth CS, Langhoff EG, Yang HC. Peloisis hepatis due to Bartonella henselae in transplantation: a hemato- hepato - renal syndrome. Transplantation 1998;65:1000-1003.
- Nadell J, Kosek J. Peliosis hepatis. Twelve cases associated with oral androgen therapy. Arch Pathol Lab Med 1977;101:405-410.
- Arnold GL, Kaplan MM. Peliosis heoatis due to oxymetholone - a clinically benign disorder. Am J Gastroenterol, 1979; 71:213-216.
- Tsirigotis P, Sella T, Shapira MY, Bitan M, Bloom A, Kiselgoff D, Levin M, Libster D, Abdul Hai A, Gesundheit B, Or R, Slavin S, Resnick I. Peliosis hepatis following treatment with androgen-steroids in patients with bone marrow failure syndromes. Haematologica. 2007;92:106-110.
- Vignaux O, Legmann P, de Pinieux G, Chaussade S, Spaulding C, Couturier D, Bonnin A. Hemorrhagic necrosis due to peliosis hepatis: imaging findings and pathological correlation. Eur Radiol 1999;9:454-456.
- Jacquermin E, Pariente D, Fabre M, Huault G, Valayer J, Bernard O. Peliosis hepatis with initial presentation as acute hepatic failure and intraperitoneal hemorrhage in children. J Hepatol 1999; 30:1146-1150.
- Warfel KA, Ellis GH. Peliosis of the spleen. Report of a case and review of the literature. Arch Pathol Lab Med 1982;106:99-100.
- Gouya H, Vignaux O, Legmann P, de Pigneux G, Bonnin A. Peliosis hepatis: triphasic helical CT and dynamic MRI findings. Abdom Imaging 2001; 26:507–509.
Copyright and license
Copyright © 2010 The Author(s). This is an open access article distributed under the Creative Commons Attribution License (CC BY), which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.