Abstract

Amaç: Anemi, hemoglobin düzeyinin düşük olduğu bir durum olarak tanımlanır. İrisin (Ir) kasla ilişkili bir faktördü. Yağ asidi bağlayıcı proteinler (FABP), hücre içi yağ asidi taşınmasında rol oynar. Çalışmanın amacı, Ir ve FABP4 düzeylerinin soğukluk, yorgunluk ve Demir eksikliği ile ilgili öğrenme güçlükleri gibi semptomlarla bağlantılı olup olmadığını araştırmaktı .

Gereç ve Yöntemler: Çalışmamızda bu üç demir eksikliği döneminin, kontrol grubu ile birlikte, demir tedavisi öncesi ve sonrası serum ve idrar Ir ve FABP4 düzeylerine olan etkileri değerlendirildi.

Bulgular: Bu çalışmada, medyan serum Ir düzeyleri hasta ve kontrol grupları arasında istatistiksel olarak anlamlı farklılıklar gösterdi, tedaviden önce hasta gruplarında düzeyler daha düşüktü (p=0,040, p<0,001 ve p <0,001). Tedaviden sonra, tüm hasta gruplarında medyan serum Ir düzeylerinde anlamlı bir artış kaydedildi (p=0,003, p=0,023 ve p= 0,014).

Sonuç: Çalışmamızda demir eksikliğinde görülen üşüme hissi ve bilişsel fonksiyonlarda azalmanın serum Ir düzeyi ile ilişkili olabileceğini saptadık.

Keywords: FABP4, Irisin, Iron deficiency, Iron deficiency anemia

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1.
Selmanoğlu A, Akarsu S, Aydın S. Investigation of the role of irisin and FABP4 in iron deficiency anemia. Turk J Pediatr Dis [Internet]. 2025 Jul. 1 [cited 2025 Jul. 7];:1-7. Available from: https://turkjpediatrdis.org/article/view/1105